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Document Type |
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Article In Journal |
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Document Title |
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iPhos-PseEn: identifying phosphorylation sites in proteins by fusing different pseudo components into an ensemble classifier iPhos-PseEn: identifying phosphorylation sites in proteins by fusing different pseudo components into an ensemble classifier |
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Document Language |
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English |
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Abstract |
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Protein phosphorylation is a posttranslational modification (PTM or PTLM),
where a phosphoryl group is added to the residue(s) of a protein molecule. The
most commonly phosphorylated amino acids occur at serine (S), threonine (T), and
tyrosine (Y). Protein phosphorylation plays a significant role in a wide range of
cellular processes; meanwhile its dysregulation is also involved with many diseases.
Therefore, from the angles of both basic research and drug development, we are
facing a challenging problem: for an uncharacterized protein sequence containing
many residues of S, T, or Y, which ones can be phosphorylated, and which ones
cannot? To address this problem, we have developed a predictor called iPhos-PseEn
by fusing four different pseudo component approaches (amino acids’ disorder scores,
nearest neighbor scores, occurrence frequencies, and position weights) into an
ensemble classifier via a voting system. Rigorous cross-validations indicated that
the proposed predictor remarkably outperformed its existing counterparts. For the
convenience of most experimental scientists, a user-friendly web-server for iPhos-
PseEn has been established at http://www.jci-bioinfo.cn/iPhos-PseEn, by which
users can easily obtain their desired results without the need to go through the
complicated mathematical equations involved. |
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ISSN |
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2732-3404 |
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Journal Name |
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Oncotarget |
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Volume |
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7 |
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Issue Number |
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32 |
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Publishing Year |
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1437 AH
2016 AD |
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Article Type |
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Article |
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Added Date |
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Wednesday, July 12, 2017 |
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Researchers
| Wang-Ren Qiu | Qiu, Wang-Ren | Researcher | Doctorate | |
| Xuan Xiao | Xiao, Xuan | Researcher | Doctorate | |
| Zhao-Chun Xu | Xu, Zhao-Chun | Researcher | Doctorate | |
| Kuo-Chen Chou | Chou, Kuo-Chen | Researcher | Doctorate | |
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