Functional & Developmental Genomics Research Program
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One of the most exciting research challenges of today is to understand how a single cell, represented by the fertilized egg, can give rise to an entire fully formed new organism. This process involves the differentiation of a wide variety of cell types and subtypes which must be organized within a complex architecture to create a functioning adult. Such orchestrated process is very well controlled by a complex and interlinked network of cell signalling. Interestingly, the mechanisms which control embryonic development are also critical in human disease. Therefore, improving our understanding of many disease processes and disease-related genes requires us to begin by understanding their role in embryonic development.
Our research in the Functional and Developmental Genomics program seeks to utilise a wide range of genomic, genetic, molecular and cell biological approaches to improve our understanding of key developmental mechanisms. Using a sophisticated bio-imaging, large scale genomics and cross-species comparisons, we aim to shed light and unravel some of the complexity of one of the most promising areas of genomic research.
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Goals:
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To understand how a single cell transforms into a fully functional organism by elucidating the cellular changes which occur during early and late embryonic development. |
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To unravel the molecular mechanisms involved in reproduction, embryonic development and organogenesis. |
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To apply high-throughput and cutting-edge technologies available at CEGMR in the developmental genomics field to understand cell signalling events during embryonic development. |
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To understand how abnormal development occurs by using a wide range of experimental approaches including gene editing and gain- and loss- of function technologies. |
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To elucidate the effects of the Gene-Environment interaction on embryonic development to understand the link of these effects to the congenital malformations induction as well as other human diseases. |
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Functional & Developmental Genomics Research Group
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Dr. Muhammed Abu-Elmagd
CEGMR, King Abdulaziz University |
Dr. Mourad Assidi
CEGMR, King Abdulaziz University |
Dr. Gauthaman Kalamegam
CEGMR, King Abdulaziz University |
Dr. Muhammad Imran Naseer
CEGMR, King Abdulaziz University |
Dr. Peter Natesan Pushparaj
CEGMR, King Abdulaziz University |
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International Collaborators:
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Prof. Andrea Münsterberg
School of Biological Sciences
University of East Anglia
Norwich, NR4 7TJ
Norfolk, United Kingdom
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Prof. Grant Wheeler
School of Biological Sciences
University of East Anglia
Norwich, NR4 7TJ
United Kingdom
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