Document Details

Document Type : Article In Journal 
Document Title :
Comparative study of extrapolative factors linked with oxidative injury and anti-inflammatory status in chronic kidney disease patients experiencing cardiovascular distress
Comparative study of extrapolative factors linked with oxidative injury and anti-inflammatory status in chronic kidney disease patients experiencing cardiovascular distress
Document Language : English 
Abstract : Background Chronic kidney disease (CKD) is a group of heterogeneous abnormalities affecting the function and structure of the kidney and mostly further proceeds to cardiovascular damage prior to end stage renal disease (ESRD). The oxidative insult and inflammatory mediators have some undefined role in CKD and cardiovascular complications. It is therefore, aimed at to pin point the predictive factors in the development of cardiovascular disorder in patients with chronic kidney disease. Methods Fifty patients of CKD experiencing cardiovascular distress and twenty normal individuals having same age and sex acted as control during these observations. Blood samples (Each 5 ml) were drawn and subjected to centrifugation for 10±15 minutes to separate the serum at 4000-5000rpm. The levels of MDA, GSH, SOD, CAT, VIT C, VIT E, IL-1, TNF-alpha, nitric oxide (NO) and advanced oxidation protein products (AOPPs) were estimated and analyzed. Results The nitric oxide levels in the CKD patients decreased significantly (13.26±1.25 ng/ml) compared to controls (42.15±5.26 ng/ml). The serum vitamin E and C levels in these patients recorded 2.15±0.25 μg/ml and 0.97±0.09 μg/ml respectively as against their assigned controls which read 6.35±1.22 μg/ml and 3.29±0.25 μg/ml. Furthermore, a significantly higher level of Malondialdehyde (MDA) as1.25±0.07 nmol/ml was observed in CKD patients viz-aviz relevant control. However, the serum SOD, catalase (CAT) and GSH levels in the same patients registered a significant decline as evident from respective figures 0.07±0.002 μg/dl, 1.22±0.012 μmol/mol, and 3.25±1.05 μg/dl. The control for these was observed as0.99 ±0.06 μg/dl, 3.19±0.05 μmol/mol, and 8.64±0.03 μg/dL. On the other hand, the IL-1 levels in the CKD patients found quite higher (402.5±18.26 pg/ml). This clearly points to substantial increase in oxidative insult and reduced NO levels leading to the renal and cardiovascular damage. Conclusion Observations support the fact that the decrease in anti-oxidative capacity accompanied by higher inflammatory mediators in CKD is indicative of oxidative stress, consequently leading to CKD progression, in all probability to cardiovascular insult. The outcome reiterates that strategies be designed afresh to contain CKD progression to cardiovascular complications and ESRD. One way could be to focus on early detection of stress related to the disease. It requires analyzing the factors related to stress, such as the one reported here. Linking these factors with the symptoms could be a crucial step forward. And further, the disease could be monitored in a more disciplined manner. 
ISSN : 1932-6203 
Journal Name : PloS one 
Volume : 12 
Issue Number : 2 
Publishing Year : 1438 AH
2017 AD
Article Type : Article 
Added Date : Sunday, May 28, 2017 


Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Rasool MahmoodMahmood, Rasool InvestigatorDoctorate 
Ashraf Muhammad Abdul BasitMuhammad Abdul Basit, Ashraf ResearcherDoctorate 
Malik ArifArif, Malik ResearcherDoctorate 
Waquar SulaymanSulayman, Waquar ResearcherDoctorate 
Khan Shahida AzizShahida Aziz, Khan ResearcherDoctorate 
Qazi Mahmood HusainMahmood Husain, Qazi ResearcherDoctorate 
Ahmad WaseemWaseem, Ahmad ResearcherDoctorate 
Asif MuhammadMuhammad, Asif ResearcherDoctorate 
Khan Sami UllahSami Ullah, Khan ResearcherDoctorate 
Zaheer AhmadAhmad, Zaheer ResearcherDoctorate 


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