Document Details

Document Type : Article In Journal 
Document Title :
Identifying radiation exposure biomarkers from mouse blood transcriptome.
Identifying radiation exposure biomarkers from mouse blood transcriptome.
 
Document Language : English 
Abstract : Ionising radiation is a pleiotropic stress agent that may induce a variety of adverse effects. Molecular biomarker approaches possess promise to assess radiation exposure, however, the pleiotropic nature of ionising radiation induced transcriptional responses and the historically poor inter-laboratory performance of omics-derived biomarkers serve as barriers to identification of unequivocal biomarker sets. Here, we present a whole-genome survey of the murine transcriptomic response to physiologically relevant radiation doses, 2 Gy and 8 Gy. We used this dataset with the Random Forest algorithm to correctly classify independently generated data and to identify putative metabolite biomarkers for radiation exposure. 
ISSN : 1744-5485 
Journal Name : International journal of bioinformatics research and applications 
Volume : 9 
Issue Number : 4 
Publishing Year : 1434 AH
2013 AD 
Article Type : Article 
Added Date : Tuesday, April 5, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Daniel R HydukeHyduke, Daniel R Investigator  
Evagelia C LaiakisLaiakis, Evagelia C Researcher  
Heng-Hong LiLi, Heng-Hong Researcher  
Albert J Fornace JrFornace Jr, Albert J Researcher  

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