Center of Excellence In Genomic Medicine Research | Researches | Deciphering the structure and function of FcεRI/mast cell axis in the regulation of allergy and anaphylaxis: a functional genomics paradigm

Center of Excellence In Genomic Medicine Research

Document Details

Document Type	:	Article In Journal
Document Title	:	Deciphering the structure and function of FcεRI/mast cell axis in the regulation of allergy and anaphylaxis: a functional genomics paradigm Deciphering the structure and function of FcεRI/mast cell axis in the regulation of allergy and anaphylaxis: a functional genomics paradigm
Document Language	:	English
Abstract	:	Allergy and anaphylaxis are inflammatory disorders caused by immune reactions mainly induced by immunoglobulin-E that signal through the high-affinity FcεRI receptor to release the inflammatory mediators from innate immune cells. The FcεRI/mast cell axis is potently involved in triggering various intracellular signaling molecules to induce calcium release from the internal stores, induction of transcription factors such as NF-kB, secretion of various cytokines as well as lipid mediators, and degranulation, resulting in the induction of allergy and anaphylaxis. In this review, we discuss various cellular and molecular mechanisms triggered through FcεRI/mast cell axis in allergy and anaphylaxis with a special emphasis on the functional genomics paradigm.
ISSN	:	1420-682X
Journal Name	:	Cellular and Molecular Life Sciences
Volume	:	69
Issue Number	:	12
Publishing Year	:	1433 AH 2012 AD
Article Type	:	Article
Added Date	:	Thursday, March 10, 2016

Researchers

Researcher Name (Arabic)	Researcher Name (English)	Researcher Type	Dr Grade	Email
Jayapal Manikandan	Manikandan, Jayapal	Investigator
Narasimhan Kothandaraman	Kothandaraman, Narasimhan	Researcher
Manoor Prakash Hande	Hande, Manoor Prakash	Researcher
Peter Natesan Pushparaj	Pushparaj, Peter Natesan	Researcher

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File Name	Type	Description
38509.pdf	pdf

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