Document Details

Document Type : Article In Journal 
Document Title :
Role of gut microbiota in obesity, type 2 diabetes and Alzheimer’s disease
Role of gut microbiota in obesity, type 2 diabetes and Alzheimer’s disease
 
Document Language : English 
Abstract : In recent years, there is a growing interest in research to investigate the importance of gut microbiome in health and diseases. This opens a new area of research for the role of microbial flora of the human gut in inflammation, energy homeostasis, pathogenesis of obesity and other associated disorders. Recent studies propose association of the gut microbiome with development of obesity and metabolic syndromes, such as type 2 diabetes mellitus (T2DM). The T2DM is a metabolic disease that is mainly caused by obesity-linked insulin resistance. The vascular effects of obesity appears to play a role in the development of Alzheimer's disease (AD) that is one of the rapidly growing diseases of a late stage of life all over the world. Studies from both humans and mice models have been demonstrated the engagement of gut microbial flora in the pathogenesis of obesity and host metabolism. The aim of this review is to discuss the current findings that may explain the cascade of gut microbial flora participation in the development of obesity, T2DM and further initiation of AD. In addition, the available data regarding the mechanisms that have been proposed to elucidate the role of gut microbiota in weight gain and possible cause of T2DM and AD have been examined. 
ISSN : 1871-5273 
Journal Name : CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorder 
Volume : 13 
Issue Number : 2 
Publishing Year : 1434 AH
2013 AD 
Article Type : Article 
Added Date : Tuesday, March 15, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Muhammad I NaseerI Naseer, Muhammad Researcher  
Fehmida BibiBibi, Fehmida Researcher  
Mohammed Al-QahtaniAl-Qahtani, Mohammed Researcher  
Adeel G ChaudharyG Chaudhary, Adeel Researcher  
Esam I AzharI Azhar, Esam Researcher  
Mohammad A KamalA Kamal, Mohammad Researcher  
Muhammad YasirYasir, Muhammad Investigator  

Files

File NameTypeDescription
 38531.pdf pdf 

Back To Researches Page