Document Details

Document Type : Article In Journal 
Document Title :
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
Document Language : English 
Abstract : Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field. 
ISSN : 1476-5403 
Journal Name : Cell Death & Differentiation 
Volume : 25 
Issue Number : 3 
Publishing Year : 1439 AH
2018 AD
Article Type : Article 
Added Date : Sunday, June 23, 2019 


Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Lorenzo GalluzziGalluzzi, Lorenzo InvestigatorDoctorate 
Ilio VitaleVitale, Ilio ResearcherDoctorate 
Stuart A. AaronsonAaronson, Stuart A.ResearcherDoctorate 
John M. AbramsAbrams, John M.ResearcherDoctorate 
Dieter AdamAdam, Dieter ResearcherDoctorate 
Patrizia AgostinisAgostinis, Patrizia ResearcherDoctorate 
Emad S. AlnemriAlnemri, Emad S.ResearcherDoctorate 
Lucia AltucciAltucci, Lucia ResearcherDoctorate 
Ivano AmelioAmelio, Ivano ResearcherDoctorate 
David W. AndrewsAndrews, David W.ResearcherDoctorate 


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