Document Details

Document Type : Article In Journal 
Document Title :
Implications of prognostic variables in the assessment of autoimmunity in hepatitis C patients receiving interferon therapy
Implications of prognostic variables in the assessment of autoimmunity in hepatitis C patients receiving interferon therapy
 
Document Language : English 
Abstract : Systematic administration of interferon-alpha (INF-alpha) is considered as the backbone of HCV therapy since 1991. Interferon (IFN) therapy can cause vasculitis, glomerulonephritis, cryoglobulinemia and certain other autoimmune diseases such as sialoadentitis, lichen planus and thyroiditis. Related to the factors of interferons, extensively studied gland is thyroid gland. A strong association was observed between thyroid disease and HCV patient when they were exposed to IFN therapy. Vitamin D, malondialdehyde (MDA), thyroid hormones and auto antibodies were biochemically assessed from the venous blood of seventy five HCV patients and fifty healthy controls. The results of all parameters were analyzed by independent sample t-test. The results of the study demonstrated a clear picture that the levels of vitamin D decreased as compared to control but increases in case of MDA. The levels of antibody titer represent that thyroglobulin-antibody (TGAb) thyroid peroxidase-antibody (TPOAb) as well as thyroid stimulating hormone receptor-antibody (TSHRAb) were raised in the patients suffering from HCV with thyroid dysfunction as compared to control. Similarly, the levels of thyroid hormones were also elevated in the HCV patients. Antibodies generated against thyroidal enzymes leads to impaired function of these enzymes thus causing decreased synthesis of thyroid hormones. As exogenous INF triggers the release of cytokines that mediate the recruitment of immune cells with increased production of inflammatory markers lead to production of lytic granules which have direct toxic action on thyroid cells and ultimately increased lipid peroxidation of thyrocytes. The results of the present study clearly demonstrated that the decreased levels of vitamin D in HCV patients receiving IFN therapy were responsible to induce autoimmunity against thyroid gland and adjutant therapy may be helpful to alleviate the possible thyroid disorders. 
ISSN : 2814-9047 
Journal Name : Bioinformation 
Volume : 12 
Issue Number : 3 
Publishing Year : 1437 AH
2016 AD 
Article Type : Article 
Added Date : Thursday, July 20, 2017 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Mahwish AroojArooj, Mahwish ResearcherDoctorate 
Arif MalikMalik, Arif ResearcherDoctorate 
Abdul BasitBasit, Abdul ResearcherDoctorate 
Mahmood Husain QaziQazi, Mahmood HusainResearcherDoctorate 
Muhammad AsifAsif, Muhammad ResearcherDoctorate 
Mohammad Sarwar JamalJamal, Mohammad SarwarResearcherDoctorate 
Maged Mostafa MahmoudMahmoud, Maged MostafaResearcherDoctorate 
Hani ChoudhryChoudhry, Hani ResearcherDoctorate 
Peter Natesan PushparajPushparaj, Peter NatesanResearcherDoctorate 
Mahmood RasoolRasool, Mahmood ResearcherDoctoratemahmoodrasool@yahoo.com

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