Document Details
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Document Type |
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Article In Journal |
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Document Title |
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Allelic variance among ABO blood group genotypes in a population from the western region of Saudi Arabia Allelic variance among ABO blood group genotypes in a population from the western region of Saudi Arabia |
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Document Language |
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English |
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Abstract |
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Background
Characterization of the ABO blood group at the phenotype and genotype levels is clinically
essential for transfusion, forensics, and population studies. This study elucidated ABO
phenotypes and genotypes, and performed an evaluation of their distribution in individuals
from the western region of Saudi Arabia.
Methods
One-hundred and seven samples underwent standard serological techniques for ABO
blood group phenotype analysis. ABO alleles and genotypes were identified using multiplex
polymerase chain reaction, and electrophoretic analysis was performed to evaluate
the highly polymorphic ABO locus.
Results
A phenotype distribution of 37.4%, 30.8%, 24.3%, and 7.5% was found for blood groups
O, A, B, and AB respectively in our study cohort. Genotype analysis identified 10 genotype
combinations with the O01/O02 and A102/O02 genotypes being the most frequent with
frequencies of 33.6% and 14.95%, respectively. Common genotypes such as A101/A101,
A101/A102, A101/B101, B101/B101, and O01/O01 were not detected. Similarly, the rare
genotypes, cis-AB01/O02, cis-AB01/O01, and cis-AB01/A102 were not found in our
cohort. The most frequently observed allele was O02 (35.98%) followed by the A102 allele
(17.76%). Furthermore, our findings are discussed in reference to ABO allele and genotype
frequencies found in other ethnic groups.
Conclusion
The study has a significant implication on the management of blood bank and transfusion
services in Saudi Arabian patients. |
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ISSN |
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2287-979X |
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Journal Name |
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Blood research |
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Volume |
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51 |
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Issue Number |
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4 |
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Publishing Year |
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1437 AH
2016 AD |
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Article Type |
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Article |
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Added Date |
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Thursday, July 20, 2017 |
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Researchers
| Abdularahman B.O. Mohamed | Mohamed, Abdularahman B.O. | Researcher | Doctorate | |
| Salwa Ibrahim Hindawi | Hindawi, Salwa Ibrahim | Researcher | Doctorate | |
| Sameer Al-harthi | Al-harthi, Sameer | Researcher | Doctorate | |
| Qamre Alam | Alam, Qamre | Researcher | Doctorate | |
| Mohammad Zubair Alam | Alam, Mohammad Zubair | Researcher | Doctorate | |
| Absarul Haque | Haque, Absarul | Researcher | Doctorate | |
| Waseem Ahmad | Ahmad, Waseem | Researcher | Doctorate | |
| Ghazi A Damanhouri | Damanhouri, Ghazi A | Researcher | Doctorate | |
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