Document Details

Document Type : Article In Journal 
Document Title :
Allelic variance among ABO blood group genotypes in a population from the western region of Saudi Arabia
Allelic variance among ABO blood group genotypes in a population from the western region of Saudi Arabia
Document Language : English 
Abstract : Background Characterization of the ABO blood group at the phenotype and genotype levels is clinically essential for transfusion, forensics, and population studies. This study elucidated ABO phenotypes and genotypes, and performed an evaluation of their distribution in individuals from the western region of Saudi Arabia. Methods One-hundred and seven samples underwent standard serological techniques for ABO blood group phenotype analysis. ABO alleles and genotypes were identified using multiplex polymerase chain reaction, and electrophoretic analysis was performed to evaluate the highly polymorphic ABO locus. Results A phenotype distribution of 37.4%, 30.8%, 24.3%, and 7.5% was found for blood groups O, A, B, and AB respectively in our study cohort. Genotype analysis identified 10 genotype combinations with the O01/O02 and A102/O02 genotypes being the most frequent with frequencies of 33.6% and 14.95%, respectively. Common genotypes such as A101/A101, A101/A102, A101/B101, B101/B101, and O01/O01 were not detected. Similarly, the rare genotypes, cis-AB01/O02, cis-AB01/O01, and cis-AB01/A102 were not found in our cohort. The most frequently observed allele was O02 (35.98%) followed by the A102 allele (17.76%). Furthermore, our findings are discussed in reference to ABO allele and genotype frequencies found in other ethnic groups. Conclusion The study has a significant implication on the management of blood bank and transfusion services in Saudi Arabian patients. 
ISSN : 2287-979X 
Journal Name : Blood research 
Volume : 51 
Issue Number : 4 
Publishing Year : 1437 AH
2016 AD
Article Type : Article 
Added Date : Thursday, July 20, 2017 


Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Abdularahman B.O. MohamedMohamed, Abdularahman B.O.ResearcherDoctorate 
Salwa Ibrahim HindawiHindawi, Salwa IbrahimResearcherDoctorate 
Sameer Al-harthiAl-harthi, Sameer ResearcherDoctorate 
Qamre AlamAlam, Qamre ResearcherDoctorate 
Mohammad Zubair AlamAlam, Mohammad ZubairResearcherDoctorate 
Absarul HaqueHaque, Absarul ResearcherDoctorate 
Waseem AhmadAhmad, Waseem ResearcherDoctorate 
Ghazi A DamanhouriDamanhouri, Ghazi AResearcherDoctorate 


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