Document Details

Document Type : Article In Journal 
Document Title :
A lipidomic and metabolomic serum signature from nonhuman primates exposed to ionizing radiation
A lipidomic and metabolomic serum signature from nonhuman primates exposed to ionizing radiation
 
Document Language : English 
Abstract : Introduction Due to dangers associated with potential accidents from nuclear energy and terrorist threats, there is a need for high-throughput biodosimetry to rapidly assess individual doses of radiation exposure. Lipidomics and metabolomics are becoming common tools for determining global signatures after disease or other physical insult and provide a ‘‘snapshot’’ of potential cellular damage. Objectives The current study assesses changes in the nonhuman primate (NHP) serum lipidome and metabolome 7 days following exposure to ionizing radiation (IR). Methods Serum sample lipids and metabolites were extracted using a biphasic liquid–liquid extraction and analyzed by ultra performance liquid chromatography quadrupole time-of-flight mass spectrometry. Global radiation signatures were acquired in data-independent mode. 
ISSN : 1573-3882 
Journal Name : Metabolomics 
Volume : 12 
Issue Number : 5 
Publishing Year : 1437 AH
2016 AD 
Article Type : Article 
Added Date : Thursday, July 20, 2017 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Evan L. PannkukPannkuk, Evan L.ResearcherDoctorate 
Evagelia C. LaiakisLaiakis, Evagelia C.ResearcherDoctorate 
Tytus D. MakMak, Tytus D.ResearcherDoctorate 
Giuseppe AstaritaAstarita, Giuseppe ResearcherDoctorate 
Simon AuthierAuthier, Simon ResearcherDoctorate 
Karen WongWong, Karen ResearcherDoctorate 
Albert J. Fornace JrFornace Jr, Albert J.ResearcherDoctorate 

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