Document Details

Document Type : Article In Journal 
Document Title :
Vascular endothelial growth factor (VEGFA) gene variation in polycystic ovary syndrome in a Tunisian women population.
Vascular endothelial growth factor (VEGFA) gene variation in polycystic ovary syndrome in a Tunisian women population.
Document Language : English 
Abstract : Background: Polycystic ovary syndrome (PCOS) is characterized by the growth of a number of small cysts on the ovaries which leads to sex hormonal imbalance. Women who are affected by this syndrome suffer from irregular menstrual cycles, decline in their fertility, excessive hair growth, obesity, acne and most importantly cardiac function problems. The vascular endothelial growth factor (VEGF) plays a pivotal role in tissue vascularization in general and in the pathogenesis of many diseases. The PCOS was found to be associated with high expression levels of VEGF. In women who undergo assisted reproductive procedures (ART), VEGF was found to be a key mediator of other factors to control ovary angiogenesis. Here, we set out to examine the association of VEGFA gene polymorphism with PCOS and its components in a population of Tunisia women to enhance our understanding of the genetic background leading angiogenesis and vascularization abnormalities in PCOS. Methods: The association of VEGFA gene with PCOS and its components was examined in a cohort of 268 women from Tunisia involving 118 PCOS patients and 150 controls. VEGFA gene variations were assessed through the analysis of the following SNPs rs699947 (A/C), rs833061 (C/T), rs1570360 (G/A), rs833068 (G/A), rs3025020 (C/T), and rs3025039 (C/T). The linkage disequilibrium between SNPs was assessed using HAPLOVIEW software while combination of SNPs into haplotypes in the population and the reconstruction of the cladogram were carried-out by PHASE and ARLEQUIN programs, respectively. Genetic association and genotype-phenotype correlations were calculated by logistic regression and non-parametric tests (Kruskall-Wallis and Mann–Whitney tests), respectively, using StatView program. Results: We observed 10 haplotypes in our studied cohort whereH1 (ACGG), H2 (ACAG), H7 (CTGG) and H8 (CTGA) were the most frequent. We observed the association of the genotype CT of the SNP rs30225039 with PCOS phenotype (P = 0.03; OR 95 % CI = 2.05 [1.07–3.90]) and a trend for correlation of the pair of haplotypes H2/H2 with prolactin levels in plasma (P = 0.077; 193.5 ± 94.3 vs 45.7 ± 7.2). These data are consistent with literature and highlight one more time the role of vascularization in the pathogeny of PCOS. (Continued on next page) 
ISSN : 1471-2164 
Journal Name : BMC genomics 
Volume : 17 
Issue Number : 9 
Publishing Year : 1437 AH
2016 AD
Article Type : Article 
Added Date : Monday, July 17, 2017 


Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Assila Ben SalemBen Salem, Assila ResearcherDoctorate 
Fatma MegdichMegdich, Fatma ResearcherDoctorate 
Olfa KacemKacem, Olfa ResearcherDoctorate 
Malek SouayehSouayeh, Malek ResearcherDoctorate 
Faten Hachani Ben AliBen Ali, Faten HachaniResearcherDoctorate 
Sondes HizemHizem, Sondes ResearcherDoctorate 
Faouzi JanhaiJanhai, Faouzi ResearcherDoctorate 
Mounir AjinaAjina, Mounir ResearcherDoctorate 
Muhammad Abu-ElmagdAbu-Elmagd, Muhammad ResearcherDoctorate 
Mourad AssidiAssidi, Mourad ResearcherDoctorate 
Mohammed H. Al QahtaniAl Qahtani, Mohammed H.ResearcherDoctorate 
Touhami MahjoubMahjoub, Touhami ResearcherDoctorate 


File NameTypeDescription
 42010.pdf pdf 

Back To Researches Page