Document Details

Document Type : Article In Journal 
Document Title :
In vitro models of cancer stem cells and clinical applications
In vitro models of cancer stem cells and clinical applications
Document Language : English 
Abstract : Cancer cells, stem cells and cancer stem cells have for a long time played a significant role in the biomedical sciences. Though cancer therapy is more effective than it was a few years ago, the truth is that still none of the current non-surgical treatments can cure cancer effectively. The reason could be due to the subpopulation called “cancer stem cells” (CSCs), being defined as those cells within a tumour that have properties of stem cells: self-renewal and the ability for differentiation into multiple cell types that occur in tumours. The phenomenon of CSCs is based on their resistance to many of the current cancer therapies, which results in tumour relapse. Although further investigation regarding CSCs is still needed, there is already evidence that these cells may play an important role in the prognosis of cancer, progression and therapeutic strategy. Therefore, long-term patient survival may depend on the elimination of CSCs. Consequently, isolation of pure CSC populations or reprogramming of cancer cells into CSCs, from cancer cell lines or primary tumours, would be a useful tool to gain an in-depth knowledge about heterogeneity and plasticity of CSC phenotypes and therefore carcinogenesis. Herein, we will discuss current CSC models, methods used to characterize CSCs, candidate markers, characteristic signalling pathways and clinical applications of CSCs. Some examples of CSC-specific treatments that are currently in early clinical phases will also be presented in this review. 
ISSN : 1471-2164 
Journal Name : BMC Genomics 
Volume : 16 
Issue Number : 2 
Publishing Year : 1437 AH
2016 AD
Article Type : Article 
Added Date : Monday, July 17, 2017 


Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Sara S FrancoFranco, Sara SResearcherDoctorate 
Karolina SzczesnaSzczesna, Karolina ResearcherDoctorate 
Maria S. IliouIliou, Maria SResearcherDoctorate 
Mohammed Al-QahtaniAl-Qahtani, Mohammed ResearcherDoctorate 
Ali MobasheriMobasheri, Ali ResearcherDoctorate 
Julianna KobolákKobolák, Julianna ResearcherDoctorate 
András DinnyésDinnyés, András ResearcherDoctorate 


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