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Document Type |
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Article In Journal |
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Document Title |
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In vitro models of cancer stem cells and clinical applications In vitro models of cancer stem cells and clinical applications |
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Document Language |
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English |
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Abstract |
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Cancer cells, stem cells and cancer stem cells have for a long time played a significant role in the biomedical
sciences. Though cancer therapy is more effective than it was a few years ago, the truth is that still none of the
current non-surgical treatments can cure cancer effectively. The reason could be due to the subpopulation called
“cancer stem cells” (CSCs), being defined as those cells within a tumour that have properties of stem cells:
self-renewal and the ability for differentiation into multiple cell types that occur in tumours.
The phenomenon of CSCs is based on their resistance to many of the current cancer therapies, which results in tumour
relapse. Although further investigation regarding CSCs is still needed, there is already evidence that these cells may
play an important role in the prognosis of cancer, progression and therapeutic strategy. Therefore, long-term patient
survival may depend on the elimination of CSCs. Consequently, isolation of pure CSC populations or reprogramming of
cancer cells into CSCs, from cancer cell lines or primary tumours, would be a useful tool to gain an in-depth
knowledge about heterogeneity and plasticity of CSC phenotypes and therefore carcinogenesis. Herein, we will discuss
current CSC models, methods used to characterize CSCs, candidate markers, characteristic signalling pathways and
clinical applications of CSCs. Some examples of CSC-specific treatments that are currently in early clinical phases will
also be presented in this review. |
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ISSN |
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1471-2164 |
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Journal Name |
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BMC Genomics |
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Volume |
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16 |
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Issue Number |
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2 |
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Publishing Year |
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1437 AH
2016 AD |
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Article Type |
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Article |
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Added Date |
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Monday, July 17, 2017 |
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Researchers
| Sara S Franco | Franco, Sara S | Researcher | Doctorate | |
| Karolina Szczesna | Szczesna, Karolina | Researcher | Doctorate | |
| Maria S. Iliou | Iliou, Maria S | Researcher | Doctorate | |
| Mohammed Al-Qahtani | Al-Qahtani, Mohammed | Researcher | Doctorate | |
| Ali Mobasheri | Mobasheri, Ali | Researcher | Doctorate | |
| Julianna Kobolák | Kobolák, Julianna | Researcher | Doctorate | |
| András Dinnyés | Dinnyés, András | Researcher | Doctorate | |
|