Document Details

Document Type : Article In Journal 
Document Title :
A Novel four-way complex variant translocation involving chromosome 46, XY, t (4; 9; 19; 22)(q25: q34; p13. 3; q11. 2) in a chronic myeloid leukemia patient
A Novel four-way complex variant translocation involving chromosome 46, XY, t (4; 9; 19; 22)(q25: q34; p13. 3; q11. 2) in a chronic myeloid leukemia patient
 
Document Language : English 
Abstract : Philadelphia (Ph) chromosome (9;22)(q34;q11) is well established in more than 90% of chronic myeloid leukemia (CML) patients, and the remaining 5–8% of CML patients show variant and complex translocations, with the involvement of third, fourth, or fifth chromosome other than 9;22. However, in very rare cases, the fourth chromosome is involved. Here, we found a novel case of four-way Ph+ chromosome translocation involving 46,XY,t(4;9;19;22)(q25:q34;p13.3;q11.2) with CML in the chronic phase. Complete blood cell count of the CML patient was carried out to obtain total leukocytes count, hemoglobin, and platelets. Fluorescence in situ hybridization technique was used for the identification of BCR–ABL fusion gene, and cytogenetic test for the confirmation of Ph (9;22)(q34;q11) and the mechanism of variant translocation in the bone marrow. The patient is successfully treated with a dose of 400 mg/day imatinib mesylate (Gleevec). We observed a significant decrease in white blood cell count of 11.7 × 109/L after 48-month follow-up. Patient started feeling better generally. There was a reduction in the swelling of the body, fatigue, and anxiety. 
ISSN : 103-389 
Journal Name : Frontiers in Oncology 
Volume : 6 
Issue Number : 1 
Publishing Year : 1437 AH
2016 AD 
Article Type : Article 
Added Date : Wednesday, July 12, 2017 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Muhammad AsifAsif, Muhammad ResearcherDoctorate 
Mohammad Sarwar JamalJamal, Mohammad SarwarResearcherDoctorate 
Abdul Rehman KhanKhan, Abdul Rehman ResearcherDoctorate 
Muhammad Imran NaseerNaseer, Muhammad ImranResearcherDoctorate 
Abrar HussainHussain, Abrar ResearcherDoctorate 
Hani ChoudhryChoudhry, Hani ResearcherDoctorate 
Arif MalikMalik, Arif ResearcherDoctorate 
Shahida Aziz KhanKhan, Shahida AzizResearcherDoctorate 
Maged Mostafa MahmoudMahmoud, Maged MostafaResearcherDoctorate 
Ashraf AliAli, Ashraf ResearcherDoctorate 
Saima IramIram, Saima ResearcherDoctorate 
Kashif KamranKamran, Kashif ResearcherDoctorate 
Asim IqbalIqbal, Asim ResearcherDoctorate 
Zainularifeen AbduljaleelAbduljaleel, Zainularifeen ResearcherDoctorate 
Peter Natesan PushparajPushparaj, Peter NatesanResearcherDoctorate 
Mahmood RasoolRasool, Mahmood ResearcherDoctorate 

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