Center of Excellence In Genomic Medicine Research | Researches | iROS-gPseKNC: predicting replication origin sites in DNA by incorporating dinucleotide position-specific propensity into general pseudo nucleotide composition

Center of Excellence In Genomic Medicine Research

Document Details

Document Type	:	Article In Journal
Document Title	:	iROS-gPseKNC: predicting replication origin sites in DNA by incorporating dinucleotide position-specific propensity into general pseudo nucleotide composition iROS-gPseKNC: predicting replication origin sites in DNA by incorporating dinucleotide position-specific propensity into general pseudo nucleotide composition
Document Language	:	English
Abstract	:	DNA replication, occurring in all living organisms and being the basis for biological inheritance, is the process of producing two identical replicas from one original DNA molecule. To in-depth understand such an important biological process and use it for developing new strategy against genetics diseases, the knowledge of duplication origin sites in DNA is indispensible. With the explosive growth of DNA sequences emerging in the postgenomic age, it is highly desired to develop high throughput tools to identify these regions purely based on the sequence information alone. In this paper, by incorporating the dinucleotide position-specific propensity information into the general pseudo nucleotide composition and using the random forest classifier, a new predictor called iROS-gPseKNC was proposed. Rigorously cross–validations have indicated that the proposed predictor is significantly better than the best existing method in sensitivity, specificity, overall accuracy, and stability. Furthermore, a user-friendly web-server for iROS-gPseKNC has been established at http://www.jcibioinfo. cn/iROS-gPseKNC, by which users can easily get their desired results without the need to bother the complicated mathematics, which were presented just for the integrity of the methodology itself.
ISSN	:	1018-6320
Journal Name	:	Oncotarget
Volume	:	7
Issue Number	:	23
Publishing Year	:	1437 AH 2016 AD
Article Type	:	Article
Added Date	:	Wednesday, July 12, 2017

Researchers

Researcher Name (Arabic)	Researcher Name (English)	Researcher Type	Dr Grade	Email
Xuan Xiao	Xiao, Xuan	Researcher	Doctorate
Han-Xiao Ye	Ye, Han-Xiao	Researcher	Doctorate
Zi Liu	Liu, Zi	Researcher	Doctorate
Jian-Hua Jia	Jia, Jian-Hua	Researcher	Doctorate
Kuo-Chen Chou	Chou, Kuo-Chen	Researcher	Doctorate

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