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Center of Excellence In Genomic Medicine Research
Document Details
Document Type
:
Article In Journal
Document Title
:
Osteoarthritis biomarkers derived from cartilage extracellular matrix: Current status and future perspectives
Osteoarthritis biomarkers derived from cartilage extracellular matrix: Current status and future perspectives
Document Language
:
English
Abstract
:
Specific soluble biomarkers can be powerful tools for the diagnosis, prognosis and personalized management of osteoarthritis (OA). Biomarkers are potential indicators of the effect of a drug on cartilage metabolism and provide crucial information about the mechanisms of drug action. In this review, we address key questions concerning the use of biomarkers in OA management: Why do we need soluble biomarkers? What are the most widely investigated biomarkers derived from cartilage extracellular matrix? What are the most common pitfalls in interpreting soluble biomarker measurements? What are the perspectives and future research directions in this field? We review current evidence to propose that cartilage-derived soluble biomarkers are complementary ‘‘drug development tools’’ that can be applied during drug development from preclinical research to clinical evaluation. In the future, such biomarkers could be surrogate markers of clinical and/or imaging outcomes. Successful standardization and implementation of automated biomarker assays will facilitate their use in companion diagnostics in the context of personalized medicine for enhanced management of OA.
ISSN
:
1877-0657
Journal Name
:
Annals of physical and rehabilitation medicine
Volume
:
59
Issue Number
:
3
Publishing Year
:
1437 AH
2016 AD
Article Type
:
Article
Added Date
:
Tuesday, July 11, 2017
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
Y. Henrotin
Henrotin, Y.
Researcher
Doctorate
C. Sanchez
Sanchez, C.
Researcher
Doctorate
A.C. Bay-Jensen
Bay-Jensen, A.C.
Researcher
Doctorate
A. Mobasheri
Mobasheri, A
Researcher
Doctorate
Files
File Name
Type
Description
41967.pdf
pdf
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