Document Details

Document Type : Article In Journal 
Document Title :
Altered joint tribology in osteoarthritis: reduced lubricin synthesis due to the inflammatory process. New horizons for therapeutic approaches
Altered joint tribology in osteoarthritis: reduced lubricin synthesis due to the inflammatory process. New horizons for therapeutic approaches
 
Document Language : English 
Abstract : Osteoarthritis (OA) is the most common form of joint disease. This review aimed to consolidate the current evidence that implicates the inflammatory process in the attenuation of synovial lubrication and joint tissue homeostasis in OA. Moreover, with these findings, we propose some evidence for novel therapeutic strategies for preventing and/or treating this complex disorder. The studies reviewed support that inflammatory mediators participate in the onset and progression of OA after joint injury. The flow of pro-inflammatory cytokines following an acute injury seems to be directly associated with altered lubricating ability in the joint tissue. The latter is associated with reduced level of lubricin, one of the major joint lubricants. Future research should focus on the development of new therapies that attenuate the inflammatory process and restore lubricin synthesis and function. This approach could support joint tribology and synovial lubrication leading to improved joint function and pain relief. 
ISSN : 1877-0657 
Journal Name : Annals of physical and rehabilitation medicine 
Volume : 59 
Issue Number : 3 
Publishing Year : 1437 AH
2016 AD 
Article Type : Article 
Added Date : Tuesday, July 11, 2017 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
M.A. SzychlinskaSzychlinska, M.A. ResearcherDoctorate 
R. LeonardiLeonardi, R. ResearcherDoctorate 
R. LeonardiLeonardi, R. ResearcherDoctorate 
M. Al-QahtaniAl-Qahtani, M. ResearcherDoctorate 
A. MobasheriMobasheri, A. ResearcherDoctorate 
G. MusumeciMusumeci, G. ResearcherDoctorate 

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