Document Details

Document Type : Article In Conference 
Document Title :
Role of miRNAs in human cancer metastasis: Implications for therapeutic intervention.
Role of miRNAs in human cancer metastasis: Implications for therapeutic intervention.
Document Language : English 
Abstract : tMetastasis is the spread and growth of localized cancer to new locations in the body and is consideredthe main cause of cancer-related deaths. Metastatic cancer cells display distinct genomic and epigenomicprofiles and almost universally an aggressive pathophysiology. A better understanding of the molecu-lar mechanisms and regulation of metastasis, including how metastatic tumors grow and survive in thenascent niche and the interactions of the emergent metastatic cancer cells within the local microenviron-ment may provide tools to design strategies to restrict metastatic dissemination. Aberrant microRNAs(miRNA) expression has been reported in metastatic cancer cells. MicroRNAs are known to regulatedivergent and/or convergent metastatic gene pathways including activation of reprogramming switchesduring metastasis. An in-depth understanding of role of miRNAs in the metastatic cascade may lead tothe identification of novel targets for anti-metastatic therapeutics as well as potential candidate miRNAsfor cancer treatment. This review primarily focuses on the role of miRNAs in the mechanisms of cancermetastasis as well as implications for metastatic cancer treatment. 
Conference Name : Seminars in Cancer Biology 
Publishing Year : 1438 AH
2017 AD
Number Of Pages : 15 
Article Type : Article 
Organizing Body : Elsevier 
Added Date : Tuesday, May 16, 2017 


Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Mohammad Alam JafriJafri, Mohammad AlamInvestigatorDoctorate 
Mohammed Hussein Al-QahtaniAl-Qahtani, Mohammed HusseinResearcherDoctorate 
Jerry William ShayShay, Jerry WilliamResearcherDoctorate 


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