|
Document Type |
: |
Article In Journal |
|
Document Title |
: |
Comparative Inhibition Study of Compounds Identified in the Methanolic Extract of Apamarga Kshara Against Trichomonas vaginalis Carbamate Kinase (TvCK): An Enzoinformatics Approach Comparative Inhibition Study of Compounds Identified in the Methanolic Extract of Apamarga Kshara Against Trichomonas vaginalis Carbamate Kinase (TvCK): An Enzoinformatics Approach |
|
Document Language |
: |
English |
|
Abstract |
: |
In the present study, we have identified ten compounds, namely dodecanol acid, myristic acid, neophytadiene, palmitic acid, heptadecanoic acid, linoleic acid, elaidic acid, 3-7-dimethyl acid, stearic acid and methyl eicos acid, of the methanolic extract of Apamarga Kshara by GC-MS analysis. Apamarga Kshara has been reported to be active against cervical erosion. Major causal organism for cervical erosion is Trichomonas vaginalis. However, there is a paucity of information about the mechanism of action and inhibitory effect of the biologically active natural compounds presented in A. Kshara against this organism (T. vaginalis). Therefore, present investigation was conducted to observe possible interactions of these compounds on T. vaginalis carbamate kinase using molecular docking software 'AutoDock 4.2.' Identification of the amino acid residues crucial for the interaction between T. vaginalis carbamate kinase and these natural compounds is of due scientific interest. The study will aid in efficacious and safe clinical use of the above-mentioned compounds. |
|
ISSN |
: |
1867-1462 |
|
Journal Name |
: |
Interdiscip Sci |
|
Volume |
: |
1 |
|
Issue Number |
: |
1 |
|
Publishing Year |
: |
1436 AH
2015 AD |
|
Article Type |
: |
Article |
|
Added Date |
: |
Thursday, April 28, 2016 |
|
Researchers
| Sibhghatulla Shaikh | Shaikh, Sibhghatulla | Investigator | | |
| Hamida Aaqil | Aaqil, Hamida | Researcher | | |
| Syed Mohd. Danish Rizvi | Rizvi, Syed Mohd. Danish | Researcher | | |
| Shazi Shakil | Shakil, Shazi | Researcher | | |
| Adel M. Abuzenadah | Abuzenadah, Adel M. | Researcher | | |
| Pragya Gupta | Gupta, Pragya | Researcher | | |
| Soumya Saxena | Saxena, Soumya | Researcher | | |
| Rohit Kr. Tiwari | Tiwari, Rohit Kr. | Researcher | | |
| Ajai Kumar | Kumar, Ajai | Researcher | | |
|