Document Details

Document Type : Article In Journal 
Document Title :
The role of epigenetics in personalized medicine: challenges and opportunities
The role of epigenetics in personalized medicine: challenges and opportunities
 
Document Language : English 
Abstract : Epigenetic alterations are considered to be very influential in both the normal and disease states of an organism. These alterations include methylation, acetylation, phosphorylation, and ubiquitylation of DNA and histone proteins (nucleosomes) as well as chromatin remodeling. Many diseases, such as cancers and neurodegenerative disorders, are often associated with epigenetic alterations. DNA methylation is one important modification that leads to disease. Standard therapies are given to patients; however, few patients respond to these drugs, because of various molecular alterations in their cells, which may be partially due to genetic heterogeneity and epigenetic alterations. To realize the promise of personalized medicine, both genetic and epigenetic diagnostic testing will be required. This review will discuss the advances that have been made as well as the challenges for the future. 
ISSN : 1755-8794 
Journal Name : BMC Med Genomics 
Volume : 8 
Issue Number : 1 
Publishing Year : 1436 AH
2015 AD 
Article Type : Article 
Added Date : Wednesday, April 27, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Mahmood RasoolRasool, Mahmood Investigator mahmoodrasool@yahoo.com
Arif MalikMalik, Arif Researcher  
Muhammad Imran NaseerNaseer, Muhammad ImranResearcher  
Abdul MananManan, Abdul Researcher  
Shakeel Ahmed AnsariAnsari, Shakeel AhmedResearcher  
Irshad BegumBegum, Irshad Researcher  
Mahmood Husain QaziQazi, Mahmood HusainResearcher  
Peter Natesan PushparajPushparaj, Peter NatesanResearcher  
Adel M AbuzenadahAbuzenadah, Adel MResearcher  
Mohammed Hussein Al-QahtaniAl-Qahtani, Mohammed HusseinResearcher  
Mohammad Amjad KamalKamal, Mohammad AmjadResearcher  
Siew Hua GanGan, Siew HuaResearcher  

Files

File NameTypeDescription
 38720.pdf pdf 

Back To Researches Page