Document Details

Document Type : Article In Journal 
Document Title :
Assessment of biochemical and antioxidative status in patients suffering from dengue fever
Assessment of biochemical and antioxidative status in patients suffering from dengue fever
 
Document Language : English 
Abstract : A multi-centred study was designed to collect dengue epidemiologic data from government and registered private hospitals/clinics and maintained archive of frozen specimens in bio-bank to be used for future dengue epidemic control program, and assess the epidemiology of dengue fever (DF) by evaluating biochemical and oxidative status of patients. ELISA IgM antibodies test was done to confirm DF. From August 2010 to December 2011, 101 confirmed blood samples of DF patients referred to pathology lab of Jinnah Hospital Lahore were subjected to the epidemiologic assessment by evaluating the biochemical and physiological indices and alterations of circulating antioxidants. Clinical features of DF patients and effect of fever on blood components and serum proteins of liver were recorded. The hospital stay in DF, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) showed significant difference. Significant increases in serum alanine amino transferase (ALT) (P=0.000), aspartate amino transferase (AST) (P=0.000), alkaline phosphatase (ALP) (P=0.000), malondialdehyde (MDA) along with significant decreases in total protein (TP) (P=0.000), reduced glutathione (GSH) (P=0.000), superoxide dismutase (SOD), catalase (CAT) (P=0.000), and sialic acid contents (P=0.016) were observed. A positive correlation existed between bound sialic acid levels, liver enzymes and circulating antioxidants (r=0.656, P=0.016). In the present study, alterations of circulating antioxidants in DF suggest that DF might be a metabolic response to an acute, self-limiting tropical viral infection, and a consequence of the viral inflammatory process. 
ISSN : 1672-0733 
Journal Name : J Huazhong Univ Sci Technolog Med Sci 
Volume : 35 
Issue Number : 3 
Publishing Year : 1436 AH
2015 AD 
Article Type : Article 
Added Date : Wednesday, April 27, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Mahmood RasoolRasool, Mahmood Investigator mahmoodrasool@yahoo.com
Arif MalikMalik, Arif Researcher  
Khalid Mahmud KhanKhan, Khalid MahmudResearcher  
Muhammad Saeed QureshiQureshi, Muhammad SaeedResearcher  
Beenish ShabbirShabbir, Beenish Researcher  
Sara ZahidZahid, Sara Researcher  
Muhammad AsifAsif, Muhammad Researcher  
Abdul MananManan, Abdul Researcher  
Sana RashidRashid, Sana Researcher  
Saima Rubab KhanKhan, Saima RubabResearcher  
Hafiz Muhammad ArsalanArsalan, Hafiz MuhammadResearcher  
Rabail AlamAlam, Rabail Researcher  
Mahwish AroojArooj, Mahwish Researcher  
Mahmood Husain QaziQazi, Mahmood HusainResearcher  
Adeel Gulzar Ahmed ChaudharyChaudhary, Adeel Gulzar AhmedResearcher  
Adel Mohammed AbuzenadahAbuzenadah, Adel MohammedResearcher  
Mohammed Hussain Al-QahtaniAl-Qahtani, Mohammed HussainResearcher  
Sajjad KarimKarim, Sajjad Researcher  

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