Document Details

Document Type : Article In Journal 
Document Title :
Disease associated cellular machinery in anaphylaxis - And the de novo paradigm shift.
Disease associated cellular machinery in anaphylaxis - And the de novo paradigm shift.
 
Document Language : English 
Abstract : Anaphylaxis is a sudden immune reaction against an allergen that can potentially lead to Anaphylactic Shock (AS). This immune reaction is characterized by an increase in Immunoglobulin-E (IgE) type of antibodies that bind with FcεRI receptors on mast cells to release inflammatory mediators. Various intracellular signaling molecules downstream of IgE/ FcεRI axis play a potential role in cytokine, chemokine and eicosanoid secretion as well as degranulation of immune cells causing vasodilation, vascular permeability, and reduction of intravascular volume leading to cardiovascular collapse. Here, we discuss the cellular machinery of anaphylaxis and the de novo paradigm shift in the cellular aspects of AS. 
ISSN : 0973-2063 
Journal Name : Bioinformation 
Volume : 11 
Issue Number : 1 
Publishing Year : 1436 AH
2015 AD 
Article Type : Article 
Added Date : Tuesday, April 26, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Peter Natesan PushparajPushparaj, Peter NatesanInvestigator  
Mahmood RasoolRasool, Mahmood Researcher  
Muhammad Imran NaseerNaseer, Muhammad ImranResearcher  
Laila Abdullah DamiatiDamiati, Laila AbdullahResearcher  
Narasimhan KothandaramanKothandaraman, Narasimhan Researcher  
Kalamegam GauthamanGauthaman, Kalamegam Researcher  
Sami BhalasBhalas, Sami Researcher  
Jayapal ManikandanManikandan, Jayapal Researcher  

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