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Center of Excellence In Genomic Medicine Research
Document Details
Document Type
:
Article In Journal
Document Title
:
Doping with anabolic androgenic steroids (AAS): Adverse effects on non-reproductive organs and functions
Doping with anabolic androgenic steroids (AAS): Adverse effects on non-reproductive organs and functions
Document Language
:
English
Abstract
:
Since the 1970s anabolic androgenic steroids (AAS) have been abused at ever increasing rates in competitive athletics, in recreational sports and in bodybuilding. Exceedingly high doses are often consumed over long periods, in particular by bodybuilders, causing acute or chronic adverse side effects frequently complicated by additional polypharmacy. This review summarizes side effects on non-reproductive organs and functions; effects on male and female reproduction have been recently reviewed in a parallel paper. Among the most striking AAS side effects are increases in haematocrit and coagulation causing thromboembolism, intracardiac thrombosis and stroke as well as other cardiac disturbances including arrhythmias, cardiomyopathies and possibly sudden death. 17α-alkylated AAS are liver toxic leading to cholestasis, peliosis, adenomas and carcinomas. Hyperbilirubinaemia can cause cholemic nephrosis and kidney failure. AAS abuse may induce exaggerated self-confidence, reckless behavior, aggressiveness and psychotic symptoms. AAS withdrawal may be accompanied by depression and suicidal intentions. Since AAS abuse is not or only reluctantly admitted physicians should be aware of the multitude of serious side effects when confronted with unclear symptoms.
ISSN
:
1573-2606
Journal Name
:
Rev Endocr Metab Disord
Volume
:
16
Issue Number
:
3
Publishing Year
:
1436 AH
2015 AD
Article Type
:
Article
Added Date
:
Tuesday, April 26, 2016
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
Eberhard Nieschlag
Nieschlag, Eberhard
Investigator
eberhard.nieschlag@ukmuenster.de
Elena Vorona
Vorona, Elena
Researcher
Files
File Name
Type
Description
38696.pdf
pdf
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