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Document Type |
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Article In Journal |
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Document Title |
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Osteoarthritis in the XXIst century: risk factors and behaviours that influence disease onset and progression Osteoarthritis in the XXIst century: risk factors and behaviours that influence disease onset and progression |
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Document Language |
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English |
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Abstract |
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Osteoarthritis (OA) is a growing public health problem across the globe, affecting more than half of the over 65 population. In the past, OA was considered a wear and tear disease, leading to the loss of articular cartilage and joint disability. Nowadays, thanks to advancements in molecular biology, OA is believed to be a very complex multifactorial disease. OA is a degenerative disease characterized by "low-grade inflammation" in cartilage and synovium, resulting in the loss of joint structure and progressive deterioration of cartilage. Although the disease can be dependent on genetic and epigenetic factors, sex, ethnicity, and age (cellular senescence, apoptosis and lubricin), it is also associated with obesity and overweight, dietary factors, sedentary lifestyle and sport injuries. The aim of this review is to highlight how certain behaviors, habits and lifestyles may be involved in the onset and progression of OA and to summarize the principal risk factors involved in the development of this complicated joint disorder. |
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ISSN |
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1422-0067 |
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Journal Name |
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Int J Mol Sci |
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Volume |
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16 |
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Issue Number |
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3 |
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Publishing Year |
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1436 AH
2015 AD |
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Article Type |
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Article |
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Added Date |
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Tuesday, April 26, 2016 |
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Researchers
| Giuseppe Musumeci | Musumeci, Giuseppe | Investigator | | g.musumeci@unict.it |
| Flavia Concetta Aiello | Aiello, Flavia Concetta | Researcher | | flaviayellow@tiscali.it |
| Marta Anna Szychlinska | Szychlinska, Marta Anna | Researcher | | mszychlinska@unict.it |
| Michelino Di Rosa | Rosa, Michelino Di | Researcher | | mdirosa@unict.it |
| Paola Castrogiovanni | Castrogiovanni, Paola | Researcher | | pacastro@unict.it |
| Ali Mobasheri | Mobasheri, Ali | Researcher | | a.mobasheri@surrey.ac.uk |
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