Document Details

Document Type : Article In Journal 
Document Title :
Nutrigenomics, Inflammaging, and Osteoarthritis
Nutrigenomics, Inflammaging, and Osteoarthritis
 
Document Language : English 
Abstract : Osteoarthritis (OA) is a painful condition affecting over 40% of people aged over 65 years old. It has been established that it involves considerable local inflammation and, as such, is the classic example of inflammaging; a condition for which age-related inflammation is a contributing factor. Nutrigenomics is the study of the effects of foods and food constituents on gene expression and is becoming of great interest to both patients with OA as well as and clinicians and scientists interested in development of novel therapies for OA. One strong motivation behind this avenue of research is the fact that there are no proven effective treatments that can arrest or reverse OA. Inflammaging in relation to the OA joint is a complex topic involving cytokines and reactive oxygen species. This review discusses these together with the contribution of loss of muscle function to the progression of OA. This review the latest literature on nutraceuticals regarded as offering the best therapeutic potential. These include resveratrol from red wine grapes and epigallocatechin gallate (EGCG) from green tea. It is too early to provide definitive answers as to their effectiveness, but there is clearly sufficient data to warrant further investigation. 
ISSN : 1118930452 
Journal Name : Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods, Second Edition 
Volume : 1 
Issue Number : 1 
Publishing Year : 1436 AH
2015 AD 
Article Type : Article 
Added Date : Monday, April 25, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Ali MobasheriMobasheri, Ali Investigator  
Richard Barrett-JolleyBarrett-Jolley, Richard Researcher  
Caroline A. StauntonStaunton, Caroline A.Researcher  
Chris FordFord, Chris Researcher  
Yves HenrotinHenrotin, Yves Researcher  

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