Document Details

Document Type : Article In Journal 
Document Title :
Physicochemical and biomechanical stimuli in cell-based articular cartilage repair
Physicochemical and biomechanical stimuli in cell-based articular cartilage repair
 
Document Language : English 
Abstract : Articular cartilage is a unique load-bearing connective tissue with a low intrinsic capacity for repair and regeneration. Its avascularity makes it relatively hypoxic and its unique extracellular matrix is enriched with cations, which increases the interstitial fluid osmolarity. Several physicochemical and biomechanical stimuli are reported to influence chondrocyte metabolism and may be utilized for regenerative medical approaches. In this review article, we summarize the most relevant stimuli and describe how ion channels may contribute to cartilage homeostasis, with special emphasis on intracellular signaling pathways. We specifically focus on the role of calcium signaling as an essential mechanotransduction component and highlight the role of phosphatase signaling in this context. 
ISSN : 1534-6307 
Journal Name : Curr Rheumatol Rep 
Volume : 17 
Issue Number : 3 
Publishing Year : 1436 AH
2015 AD 
Article Type : Article 
Added Date : Thursday, April 21, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Holger JahrJahr, Holger Investigator  
Csaba MattaMatta, Csaba Researcher  
Ali MobasheriMobasheri, Ali Researcher  

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