Document Details

Document Type : Article In Journal 
Document Title :
MicroRNAs as potential drug targets for therapeutic intervention in colorectal cancer
MicroRNAs as potential drug targets for therapeutic intervention in colorectal cancer
 
Document Language : English 
Abstract : INTRODUCTION: MicroRNAs (miRNAs) are small (19 - 22 nucleotide), non-protein-coding RNA segments that function as master regulators of hundreds of genes simultaneously in both normal and malignant cells. In colorectal cancer (CRC) miRNAs are deregulated and have critical roles in initiation and progression of CRC by interacting with various oncogenes and tumor suppressor genes including APC, KRAS and p53, or by modulating downstream signal transduction pathways. Numerous promising miRNAs have emerged as potential drug targets for therapeutic intervention and possible candidates for replacement therapy in CRC. AREAS COVERED: In this review the authors summarize the available information on miRNAs and their role in CRC. The authors point out specific miRNAs as potential drug targets and those having a significant role in gene activation and gene silencing during the process of CRC development, to highlight their importance as possible therapeutic candidates for the treatment of CRC. EXPERT OPINION: Targeting miRNAs provides an emerging opportunity to develop effective miRNA-based replacement therapy or antagonists to alter expression in colon cancer patient tumors. However, the biggest challenge is to overcome obstacles associated with pharmacokinetics, delivery and toxicity in order to translate the potential of miRNAs into efficacious anticancer drugs. 
ISSN : 1744-7631 
Journal Name : Expert Opin Ther Targets 
Volume : 19 
Issue Number : 12 
Publishing Year : 1436 AH
2015 AD 
Article Type : Article 
Added Date : Thursday, April 21, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Mohammad Alam JafriJafri, Mohammad AlamInvestigator  
Syed Kashif ZaidiZaidi, Syed KashifResearcher  
Shakeel Ahmed AnsariAnsari, Shakeel AhmedResearcher  
Mohammed Hussein Al-QahtaniAl-Qahtani, Mohammed HusseinResearcher  
Jerry W ShayShay, Jerry WResearcher  

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