Document Details

Document Type : Article In Journal 
Document Title :
Decreasing initial telomere length in humans intergenerationally understates age-associated telomere shortening.
Decreasing initial telomere length in humans intergenerationally understates age-associated telomere shortening.
 
Document Language : English 
Abstract : Telomere length shortens with aging, and short telomeres have been linked to a wide variety of pathologies. Previous studies suggested a discrepancy in age-associated telomere shortening rate estimated by cross-sectional studies versus the rate measured in longitudinal studies, indicating a potential bias in cross-sectional estimates. Intergenerational changes in initial telomere length, such as that predicted by the previously described effect of a father's age at birth of his offspring (FAB), could explain the discrepancy in shortening rate measurements. We evaluated whether changes occur in initial telomere length over multiple generations in three large datasets and identified paternal birth year (PBY) as a variable that reconciles the difference between longitudinal and cross-sectional measurements. We also clarify the association between FAB and offspring telomere length, demonstrating that this effect is substantially larger than reported in the past. These results indicate the presence of a downward secular trend in telomere length at birth over generational time with potential public health implications. 
ISSN : 1474-9726 
Journal Name : Aging cell 
Volume : 14 
Issue Number : 4 
Publishing Year : 1436 AH
2015 AD 
Article Type : Article 
Added Date : Wednesday, April 20, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Brody HolohanHolohan, Brody Investigator  
Tim De MeyerMeyer, Tim DeResearcher  
Kimberly BattenBatten, Kimberly Researcher  
Massimo ManginoMangino, Massimo Researcher  
Steven C. HuntHunt, Steven C.Researcher  
Sofie BekaertBekaert, Sofie Researcher  
Marc L. De BuyzereDe Buyzere, Marc L.Researcher  
Ernst R. RietzschelRietzschel, Ernst R.Researcher  
Tim D. SpectorSpector, Tim D.Researcher  
Woodring E. WrightWright, Woodring E.Researcher  
Jerry W. ShayShay, Jerry W.Researcher  

Files

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