Document Details

Document Type : Article In Journal 
Document Title :
Incidence and potential causative factors associated with chronic benign neutropenia in the Kingdom of Saudi Arabia
Incidence and potential causative factors associated with chronic benign neutropenia in the Kingdom of Saudi Arabia
 
Document Language : English 
Abstract : BACKGROUND: Benign neutropenia often presents in certain populations without any genotype nor phenotype. Middle East countries are among the regions where endemic cases of chronic benign neutropenia are reported in the general population with an incidence of approximately between 10-15%. Not many studies have been performed to ascertain the cause or burden associated with this condition. The objective of the current study was to identify the frequency and characterize the consequences of chronic benign neutropenia in the country of Saudi Arabia. RESULTS: Benign neutropenia was found to be high in the Saudi Arabia general population (up to 20%), with an average neutrophil count of 1.48 (range 0.99 - 1.95 × 10(9)cells/L), with Saudis having a higher incidence of chronic benign neutropenia compared to non-Saudis (p = <0.05). Complete blood count analyses showed significant difference in the total white cell count of neutrophils (p < 0.0001), WBC (p < 0.0001), lymphocytes (p < 0.001), monocytes (p < 0.001), eosinophils (p = 0.013) as well as the CD19 B cells (p = 0.008). CONCLUSIONS: Our study is the first to carefully quantitate benign neutropenia in Saudi Arabia. We identified that this condition is prevalent in the middle aged population (18 years to 55 years). These individuals not only had lower neutrophil counts, but also reduced peripheral blood cells types, especially the B-lymphocyte population (CD19 subset). As B-lymphocytes are involved in antibody production and antigen recognition, a decrease might easily predispose the individuals to infectious agents. As such more mechanistic studies need to be undertaken to understand the cause and potential long-term consequences of benign neutropenia. 
ISSN : 1753-6561 
Journal Name : BMC Proc 
Volume : 9 
Issue Number : 2 
Publishing Year : 1436 AH
2015 AD 
Article Type : Article 
Added Date : Wednesday, April 20, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Mamdooh GariGari, Mamdooh Investigator  
Mohammed DakhakhniDakhakhni, Mohammed Researcher  
Abdullah GariGari, Abdullah Researcher  
Erada AlshihriAlshihri, Erada Researcher  
Rowan Al-JahdaliAl-Jahdali, Rowan Researcher  
Kothandaraman NarasimhanNarasimhan, Kothandaraman Researcher  
Shen LiangLiang, Shen Researcher  
Fatin Al-SayesAl-Sayes, Fatin Researcher  
Gauthaman KalamegamKalamegam, Gauthaman Researcher  
Adeel ChaudharyChaudhary, Adeel Researcher  
Adel AbuzenadahAbuzenadah, Adel Researcher  
Mohammed Al-QahtaniAl-Qahtani, Mohammed Researcher  

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