Document Details

Document Type : Article In Journal 
Document Title :
A nanotechnological approach to the management of Alzheimer disease and type 2 diabetes
A nanotechnological approach to the management of Alzheimer disease and type 2 diabetes
 
Document Language : English 
Abstract : Alzheimer's disease (AD) and type 2 diabetes (T2D) are both prevalent in older individuals and have gained significant attention due to alarming rates of increase. The high incidences of these diseases pose a great socioeconomic burden and cause major public health concerns worldwide. A number of studies have established potential links between AD and T2D, supporting the hypothesis that T2D is linked with an increased risk of AD and that controlling diabetes could have a positive impact on the prevention of AD. At present, both diseases lack precise diagnostic approaches for early intervention and effective cure. Further, the currently available diagnostic tools for AD screening are insufficiently sensitive and robust for preventive measures. Although several drugs are used for the treatment of both these diseases, none of these drugs offers complete remission of the disease, merely symptomatic relief. Moreover, these drugs have limited efficacy because of problems such as conventional drug delivery systems beyond the blood brain barrier, a lack of target specificity and diminished potency. From this perspective, the emerging field of nanotechnology has offered new techniques and tools to overcome these challenges. In this review, we discuss the direct and indirect limitations of existing therapies and describe alternative potential nanotechnological approaches that could be utilized to overcome these limitations. New insight in the field of nanomedicine is necessary for early diagnosis, the development of novel drug therapies, the action of drugs and prevention, as well as for gaining an in-depth understanding of the complex biology of both diseases. 
ISSN : 1871-5273 
Journal Name : CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorder 
Volume : 13 
Issue Number : 3 
Publishing Year : 1434 AH
2013 AD 
Article Type : Article 
Added Date : Thursday, April 14, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Qamre AlamAlam, Qamre Researcher  
Mohammad ZubairAlamZubairAlam, Mohammad Researcher  
Sajjad KarimKarim, Sajjad Researcher  
Siew H GanH Gan, Siew Researcher  
Mohammad A KamalA Kamal, Mohammad Researcher  
Asif Jiman-FataniJiman-Fatani, Asif Researcher  
Ghazi A DamanhouriA Damanhouri, Ghazi Researcher  
Adel M AbuzenadahM Abuzenadah, Adel Researcher  
Adeel G ChaudharyG Chaudhary, Adeel Researcher  
Absarul HaqueHaque, Absarul Investigator  

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