Document Details
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Document Type |
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Article In Journal |
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Document Title |
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Differential mobility spectrometry with nanospray ion source as a compact detector for small organics and inorganics Differential mobility spectrometry with nanospray ion source as a compact detector for small organics and inorganics |
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Document Language |
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English |
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Abstract |
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Electrospray ionization (ESI) is an important tool in
chemical and biochemical survey and targeted analysis in
many applications. For chemical detection and identification
electrospray is usually used with mass spectrometry (MS).
However, for screening and monitoring of chemicals of interest
in light, low power field-deployable instrumentation, an alternative
detection technology with chemical selectivity would be
highly useful, especially since small, lightweight, chip-based
gas and liquid chromatographic technologies are being developed.
Our initial list of applications requiring portable instruments
includes chemical surveys on Mars, medical diagnostics
based on metabolites in biological samples, and water quality
analysis. In this report, we evaluate ESI-Differential Mobility
Spectrometry (DMS) as a compact, low-power alternative to
MS detection. Use of DMS for chemically-selective detection
of ESI suffers in comparison with mass spectrometry because
portable MS peak capacity is greater than that of DMS by 10X
or more, but the development of light, fast chip chromatography
offers compensating resolution. Standalone DMS provides
the chemical selectivity familiar from DMS-MS publications,
and exploits the sensitivity of ion detection. We find that submicroliter-per-minute
flows and a correctly-designed interface
prepare a desolvated ion stream that enables DMS to act
as an effective ion filter. Results for a several small organic
biomarkers and metabolites, including citric acid, azelaic acid,
n hexanoylglycine, thymidine, and caffeine, as well as
compounds such as dinitrotoluene and others, have been
characterized and demonstrate selective detection. Waterquality-related
halogen-containing anions, fluoride through
bromate, contained in liquid samples are also isolated by
DMS. A reaction-chamber interface is highlighted as most
practical for portable ESI-DMS instrumentation. |
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ISSN |
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1435-6163 |
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Journal Name |
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International Journal for Ion Mobility Spectrometry |
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Volume |
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16 |
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Issue Number |
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3 |
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Publishing Year |
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1434 AH
2013 AD |
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Article Type |
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Article |
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Added Date |
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Sunday, April 10, 2016 |
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Researchers
| Stephen L Coy | Coy, Stephen L | Investigator | | |
| Evgeny V Krylov | Krylov, Evgeny V | Researcher | | |
| Erkinjon G Nazarov | Nazarov, Erkinjon G | Researcher | | |
| Albert J Fornace Jr | Fornace Jr, Albert J | Researcher | | |
| Richard D Kidd | Kidd, Richard D | Researcher | | |
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