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Center of Excellence In Genomic Medicine Research
Document Details
Document Type
:
Article In Journal
Document Title
:
Signal Propagation in Protein Interaction Network during Colorectal Cancer Progression
Signal Propagation in Protein Interaction Network during Colorectal Cancer Progression
Document Language
:
English
Abstract
:
Colorectal cancer is generally categorized into the following four stages according to its development or serious degree: Dukes A, B, C, and D. Since different stage of colorectal cancer actually corresponds to different activated region of the network, the transition of different network states may reflect its pathological changes. In view of this, we compared the gene expressions among the colorectal cancer patients in the aforementioned four stages and obtained the early and late stage biomarkers, respectively. Subsequently, the two kinds of biomarkers were both mapped onto the protein interaction network. If an early biomarker and a late biomarker were close in the network and also if their expression levels were correlated in the Dukes B and C patients, then a signal propagation path from the early stage biomarker to the late one was identified. Many transition genes in the signal propagation paths were involved with the signal transduction, cell communication, and cellular process regulation. Some transition hubs were known as colorectal cancer genes. The findings reported here may provide useful insights for revealing the mechanism of colorectal cancer progression at the cellular systems biology level.
ISSN
:
2314-6133
Journal Name
:
BioMed research international
Volume
:
2013
Issue Number
:
0
Publishing Year
:
1434 AH
2013 AD
Article Type
:
Article
Added Date
:
Tuesday, April 5, 2016
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
Yang Jiang
Jiang, Yang
Investigator
Tao Huang
Huang, Tao
Researcher
Lei Chen
Chen, Lei
Researcher
Yu-Fei Gao
Gao, Yu-Fei
Researcher
Yudong Cai
Cai, Yudong
Researcher
Kuo-Chen Chou
Chou, Kuo-Chen
Researcher
Files
File Name
Type
Description
38441.pdf
pdf
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