Document Details

Document Type : Article In Journal 
Document Title :
CA 15-3 (Mucin-1) and physiological characteristics of breast cancer from Lahore, Pakistan
CA 15-3 (Mucin-1) and physiological characteristics of breast cancer from Lahore, Pakistan
 
Document Language : English 
Abstract : BACKGROUND: High incidence of breast cancer and its fatal effect has reached an alarming stage across the globe, including the third world countries. Many factors have been reported to be associated with the development of breast cancer but detailed structural and functional information is missing. CA 15-3 is one of the known potential tumor marker of breast cancer; however little is known about structure and functional site of this protein. Present study aims to investigate the functional role of CA 15-3 in breast cancer, especially in development and metastasis. MATERIAL AND METHODS: Hundred female breast cancer patients confirmed by histopathological reports were included in the study. Their physiological characters were recorded in a performa. Enzyme linked immunosorbent assay (ELISA) technique was used to estimate serum CA 15-3 level. Immunohistochemistry was done for estrogen (ER), progesterone (PR) and Her2/neu receptors expression. RESULTS: The study revealed the details of physiological characteristics of female breast cancer. Mean age was 37.72 ± 5.99 and 55.05 ± 7.28 years and serum CA 15-3 (MUC1) level was 60.47 ± 8.59 and 63.17 ± 4.58 U/ml in pre and post-menopause respectively, and both groups of women had sedentary life style. Their receptor status especially of progesterone, estrogen and HER-2/neu were positive in 50% of premenopausal women and 65% of postmenopausal women. CONCLUSION: There are multiple physiological factors promoting breast cancer. High serum CA 15-3 level and hormonal imbalance of ER, PR and Her2/neu appears to be the main cause of breast cancer. It may be possible that the functional sites of these proteins may be altered which may increase the chances of metastasis in breast cancer. 
ISSN : 1513-7368 
Journal Name : Asian Pacific Journal of Cancer Prevention 
Volume : 13 
Issue Number : 10 
Publishing Year : 1433 AH
2012 AD 
Article Type : Article 
Added Date : Sunday, April 3, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Mumtaz BegumBegum, Mumtaz Investigator  
Sajjad KarimKarim, Sajjad Researcher  
Arif MalikMalik, Arif Researcher  
Rukhshan KhurshidKhurshid, Rukhshan Researcher  
Muhammad AsifAsif, Muhammad Researcher  
Asmat SalimSalim, Asmat Researcher  
Saeed Ahmed NagraNagra, Saeed Ahmed Researcher  
Ahmad ZaheerZaheer, Ahmad Researcher  
Zafar IqbalIqbal, Zafar Researcher  
Adel Mohammed AbuzenadahAbuzenadah, Adel MohammedResearcher  

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