Document Details

Document Type : Article In Journal 
Document Title :
Genomic linkage between Alzheimer's disease and type 2 diabetes
Genomic linkage between Alzheimer's disease and type 2 diabetes
 
Document Language : English 
Abstract : Alzheimer's disease (AD) is a major health concern that affects nearly every society worldwide. The disease is an irreversible, progressive and age-related neurodegenerative disorder. It is characterized by impaired cognitive function and the diffuse deposition of amyloid plaques and neurofibrillary tangles. The causes of AD and the underlying mechanisms that trigger the onset of the disease are still a matter of debate. Several epidemiological studies have shown that the development of AD is associated with type 2 diabetes mellitus (T2D). In this review, we provide evidence for the link between T2D and AD, highlighting the critical role of insulin in the pathogenesis of these diseases, and we provide information on the genes that might be involved in the interplay between these two disorders. New insight into the complex biology of AD is necessary for the early diagnosis of the disease, the development of novel drug therapies and the prevention of these health issues. 
ISSN : 1871-5273 
Journal Name : CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorder 
Volume : 13 
Issue Number : 2 
Publishing Year : 1434 AH
2013 AD 
Article Type : Article 
Added Date : Tuesday, March 15, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Taoufik NedjadiNedjadi, Taoufik Researcher  
Absarul HaqueHaque, Absarul Researcher  
Qamre AlamAlam, Qamre Researcher  
Siew H GanH Gan, Siew Researcher  
Adeel G ChaudharyG Chaudhary, Adeel Researcher  
Adel M AbuzenadahM Abuzenadah, Adel Researcher  
Ghazi A DamanhouriA Damanhouri, Ghazi Researcher  
Mohammad A KamalA Kamal, Mohammad Investigator  

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