Document Details

Document Type : Article In Journal 
Document Title :
Cilia, KIF3 molecular motor and nodal flow
Cilia, KIF3 molecular motor and nodal flow
 
Document Language : English 
Abstract : establishment of left-right asymmetry during development of vertebrate embryos depends on leftward flow in the nodal cavity. The flow is produced by the rotational movement of the posteriorly tilted nodal cilia. However, it remains poorly understood how the nodal cilia are tilted posteriorly, and how the directionality of the flow is translated into gene expression patterns in the embryo. Recent studies have identified signaling molecules involved in these processes. First, planar cell polarity signaling has been shown to be involved in the posterior positioning of the basal bodies of nodal cilia, which leads to the posterior tilting of their rotation axes. Second, identification of putative receptors and signaling molecules suggests a link between the signaling molecules delivered by the nodal flow, and downstream signaling in the cells surrounding the nodal cavity and the lateral plate mesoderm. 
ISSN : 0955-0674 
Journal Name : Current opinion in cell biology 
Volume : 24 
Issue Number : 1 
Publishing Year : 1433 AH
2012 AD 
Article Type : Article 
Added Date : Monday, March 14, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Nobutaka HirokawaHirokawa, Nobutaka Investigator hirokawa@m.u-tokyo.ac.jp
Yosuke TanakaTanaka, Yosuke Researcher  
Yasushi OkadaOkada, Yasushi Researcher  

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