Document Details

Document Type : Article In Journal 
Document Title :
IL-33 attenuates EAE by suppressing IL-17 and IFN-γ production and inducing alternatively activated macrophages
IL-33 attenuates EAE by suppressing IL-17 and IFN-γ production and inducing alternatively activated macrophages
 
Document Language : English 
Abstract : Interleukin (IL)-33, a member of the IL-1 cytokine family, is an important modulator of the immune system associated with several immune-mediated disorders. High levels of IL-33 are expressed by the central nervous system (CNS) suggesting a potential role of IL-33 in autoimmune CNS diseases. We have investigated the expression and function of IL-33 in the development of experimental autoimmune encephalomyelitis (EAE) in mice. We report here that IL-33 and its receptor ST2 (IL-33Rα) are highly expressed in spinal cord tissue, and ST2 expression is markedly increased in the spinal cords of mice with EAE. Furthermore, ST2-deficient (ST2(-/-) ) mice developed exacerbated EAE compared with wild-type (WT) mice while WT, but not ST2(-/-) EAE mice treated with IL-33 developed significantly attenuated disease. IL-33-treated mice had reduced levels of IL-17 and IFN-γ but produced increased amounts of IL-5 and IL-13. Lymph node and splenic macrophages of IL-33-treated mice showed polarization toward an alternatively activated macrophage (M2) phenotype with significantly increased frequency of MR(+) PD-L2(+) cells. Importantly, adoptive transfer of these IL-33-treated macrophages attenuated EAE development. Our data therefore demonstrate that IL-33 plays a therapeutic role in autoimmune CNS disease by switching a predominantly pathogenic Th17/Th1 response to Th2 activity, and by polarization of anti-inflammatory M2 macrophages. 
ISSN : 1521-4141 
Journal Name : European journal of immunology 
Volume : 42 
Issue Number : 7 
Publishing Year : 1433 AH
2012 AD 
Article Type : Article 
Added Date : Thursday, March 10, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Hui‐Rong JiangJiang, Hui‐Rong Investigator huirong.jiang@strath.ac.uk
Marija MilovanovićMilovanović, Marija Researcher  
Debbie AllanAllan, Debbie Researcher  
Wanda NiedbalaNiedbala, Wanda Researcher  
Anne‐Galle BesnardBesnard, Anne‐Galle Researcher  
Sandra Y FukadaFukada, Sandra Y Researcher  
Jose C Alves‐FilhoAlves‐Filho, Jose C Researcher  
Dieudonnée TogbeTogbe, Dieudonnée Researcher  
Carl S GoodyearGoodyear, Carl S Researcher  
Christopher LiningtonLinington, Christopher Researcher  

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