Document Details

Document Type : Article In Journal 
Document Title :
Nitric Oxide–Induced Regulatory T Cells Inhibit Th17 but Not Th1 Cell Differentiation and Function
Nitric Oxide–Induced Regulatory T Cells Inhibit Th17 but Not Th1 Cell Differentiation and Function
 
Document Language : English 
Abstract : NO is a free radical with pleiotropic functions. We have shown earlier that NO induces a population of CD4(+)CD25(+)Foxp3(-) regulatory T cells (NO-Tregs) that suppress the functions of CD4(+)CD25(-) effector T cells in vitro and in vivo. We report in this study an unexpected finding that NO-Tregs suppressed Th17 but not Th1 cell differentiation and function. In contrast, natural Tregs (nTregs), which suppressed Th1 cells, failed to suppress Th17 cells. Consistent with this observation, NO-Tregs inhibited the expression of retinoic acid-related orphan receptor γt but not T-bet, whereas nTregs suppressed T-bet but not retinoic acid-related orphan receptor γt expression. The NO-Treg-mediated suppression of Th17 was partially cell contact-dependent and was associated with IL-10. In vivo, adoptively transferred NO-Tregs potently attenuated experimental autoimmune encephalomyelitis. The disease suppression was accompanied by a reduction of Th17, but not Th1 cells in the draining lymph nodes, and a decrease in the production of IL-17, but an increase in IL-10 synthesis. Our results therefore demonstrate the differential suppressive function between NO-Tregs and nTregs and indicate specialization of the regulatory mechanism of the immune system. 
ISSN : 0022-1767 
Journal Name : The Journal of Immun 
Volume : 191 
Issue Number : 1 
Publishing Year : 1434 AH
2013 AD 
Article Type : Article 
Added Date : Thursday, March 10, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Wanda NiedbalaNiedbala, Wanda Investigator  
Anne-Gaelle BesnardBesnard, Anne-Gaelle Researcher  
Hui R JiangJiang, Hui R Researcher  
Jose C Alves-FilhoAlves-Filho, Jose C Researcher  
Sandra Y FukadaFukada, Sandra Y Researcher  
Daniela NascimentoNascimento, Daniela Researcher  
Akio MitaniMitani, Akio Researcher  
Peter PushparajPushparaj, Peter Researcher  
Mohammed H AlqahtaniAlqahtani, Mohammed H Researcher  
Foo Y LiewLiew, Foo Y Researcher  

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