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Center of Excellence In Genomic Medicine Research
Document Details
Document Type
:
Article In Journal
Document Title
:
Motor protein KIF1A is essential for hippocampal synaptogenesis and learning enhancement in an enriched environment
Motor protein KIF1A is essential for hippocampal synaptogenesis and learning enhancement in an enriched environment
Document Language
:
English
Abstract
:
Environmental enrichment causes a variety of effects on brain structure and function. Brain-derived neurotrophic factor (BDNF) plays an important role in enrichment-induced neuronal changes; however, the precise mechanism underlying these effects remains uncertain. In this study, a specific upregulation of kinesin superfamily motor protein 1A (KIF1A) was observed in the hippocampi of mice kept in an enriched environment and, in hippocampal neurons in vitro, BDNF increased the levels of KIF1A and of KIF1A-mediated cargo transport. Analysis of Bdnf(+/-) and Kif1a(+/-) mice revealed that a lack of KIF1A upregulation resulted in a loss of enrichment-induced hippocampal synaptogenesis and learning enhancement. Meanwhile, KIF1A overexpression promoted synaptogenesis via the formation of presynaptic boutons. These findings demonstrate that KIF1A is indispensable for BDNF-mediated hippocampal synaptogenesis and learning enhancement induced by enrichment. This is a new molecular motor-mediated presynaptic mechanism underlying experience-dependent neuroplasticity.
ISSN
:
0896-6273
Journal Name
:
Neuron
Volume
:
73
Issue Number
:
4
Publishing Year
:
1433 AH
2012 AD
Article Type
:
Article
Added Date
:
Thursday, March 10, 2016
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
Makoto Kondo
Kondo, Makoto
Investigator
Yosuke Takei
Takei, Yosuke
Researcher
Nobutaka Hirokawa
Hirokawa, Nobutaka
Researcher
Files
File Name
Type
Description
38517.pdf
pdf
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