Document Details

Document Type : Article In Journal 
Document Title :
Molecular motor KIF5A is essential for GABA A receptor transport, and KIF5A deletion causes epilepsy
Molecular motor KIF5A is essential for GABA A receptor transport, and KIF5A deletion causes epilepsy
 
Document Language : English 
Abstract : KIF5 (also known as kinesin-1) family members, consisting of KIF5A, KIF5B, and KIF5C, are microtubule-dependent molecular motors that are important for neuronal function. Among the KIF5s, KIF5A is neuron specific and highly expressed in the central nervous system. However, the specific roles of KIF5A remain unknown. Here, we established conditional Kif5a-knockout mice in which KIF5A protein expression was postnatally suppressed in neurons. Epileptic phenotypes were observed by electroencephalogram abnormalities in knockout mice because of impaired GABA(A) receptor (GABA(A)R)-mediated synaptic transmission. We also identified reduced cell surface expression of GABA(A)R in knockout neurons. Importantly, we identified that KIF5A specifically interacted with GABA(A)R-associated protein (GABARAP) that is known to be involved in GABA(A)R trafficking. KIF5A regulated neuronal surface expression of GABA(A)Rs via an interaction with GABARAP. These results provide an insight into the molecular mechanisms of KIF5A, which regulate inhibitory neural transmission. 
ISSN : 0896-6273 
Journal Name : Neuron 
Volume : 76 
Issue Number : 5 
Publishing Year : 1433 AH
2012 AD 
Article Type : Article 
Added Date : Wednesday, March 9, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Kazuo NakajimaNakajima, Kazuo Investigator  
Xiling YinYin, Xiling Researcher  
Yosuke TakeiTakei, Yosuke Researcher  
Dae-Hyun SeogSeog, Dae-Hyun Researcher  
Noriko HommaHomma, Noriko Researcher  
Nobutaka HirokawaHirokawa, Nobutaka Researcher  

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