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Document Type |
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Article In Journal |
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Document Title |
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Inflammatory mediators in osteoarthritis: A critical review of the state-of-the-art, current prospects, and future challenges Inflammatory mediators in osteoarthritis: A critical review of the state-of-the-art, current prospects, and future challenges |
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Document Language |
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English |
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Abstract |
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We appreciate the efforts of Anna Litwic and her colleagues [1] for
writing a well-advised comment on our published review article entitled
“Inflammatory mediators in osteoarthritis: A critical review of the
state-of-the art, prospects, and future challenges” [2]. In their recent letter,
Litwic et al. [1] have highlighted the noteworthy results of their previous
research on the relationship between baseline inflammatory
factors and rate of radiographic development of knee osteoarthritis
(OA) over a period of 10 years in oldermen andwomen. In their original
work, they have demonstrated that baseline inflammatory factors did
not correlate with the rate of radiographic knee OA progression over
10 years. Although, at the time of writing our review article we did
not cite some of the results in this concept [3,4], in our paper, we have
clearly stated in “Section 5. Imaging techniques for diagnosis of inflammation
in OA” that “many studies have reported a weak correlation between
pain and radiographic findings, in which some patients with
advanced radiographic findings have shown no pain symptom and some
patients with pain demonstrated no radiographic signs of OA”. This indicates
that although radiographic techniques might be useful for OA diagnosis
in early stages, they are almost always unable to fully track
the progression of OA. Since finding early changes in OA by conventional
radiographic methods is usually difficult,modern imaging techniques
such as MRI and US are being increasingly used for investigating early
signs and symptoms. Here once againwe emphasize that our critical review
is in accordance with the findings reported by Litwic et al. [1] and
the other articles which have concluded the same results [5–9]. We
thank the authors for their interest in our review article and for taking
the time to highlight their own significant contributions to the field. |
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ISSN |
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8756-3282 |
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Journal Name |
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Bone |
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Volume |
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85 |
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Issue Number |
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1 |
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Publishing Year |
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1437 AH
2016 AD |
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Article Type |
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Article |
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Added Date |
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Wednesday, July 12, 2017 |
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Researchers
| Maryam Rahmati | Rahmati, Maryam | Researcher | Doctorate | |
| Ali Mobasheri | Mobasheri, Ali | Researcher | Doctorate | |
| Masoud Mozafari | Mozafari, Masoud | Researcher | Doctorate | mozafari.masoud@gmail.com |
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