Document Details
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Document Type |
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Article In Journal |
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Document Title |
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iHyd-PseCp: Identify hydroxyproline and hydroxylysine in proteins by incorporating sequence-coupled effects into general PseAAC iHyd-PseCp: Identify hydroxyproline and hydroxylysine in proteins by incorporating sequence-coupled effects into general PseAAC |
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Document Language |
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English |
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Abstract |
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Protein hydroxylation is a posttranslational modification (PTM), in which a
CH group in Pro (P) or Lys (K) residue has been converted into a COH group, or a
hydroxyl group (-OH) is converted into an organic compound. Closely associated
with cellular signaling activities, this type of PTM is also involved in some major
diseases, such as stomach cancer and lung cancer. Therefore, from the angles of both
basic research and drug development, we are facing a challenging problem: for an
uncharacterized protein sequence containing many residues of P or K, which ones
can be hydroxylated, and which ones cannot? With the explosive growth of protein
sequences in the post-genomic age, the problem has become even more urgent.
To address such a problem, we have developed a predictor called iHyd-PseCp by
incorporating the sequence-coupled information into the general pseudo amino acid
composition (PseAAC) and introducing the “Random Forest” algorithm to operate
the calculation. Rigorous jackknife tests indicated that the new predictor remarkably
outperformed the existing state-of-the-art prediction method for the same purpose.
For the convenience of most experimental scientists, a user-friendly web-server for
iHyd-PseCp has been established at http://www.jci-bioinfo.cn/iHyd-PseCp, by which
users can easily obtain their desired results without the need to go through the
complicated mathematical equations involved. |
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ISSN |
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2732-2424 |
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Journal Name |
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Oncotarget |
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Volume |
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7 |
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Issue Number |
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28 |
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Publishing Year |
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1437 AH
2016 AD |
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Article Type |
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Article |
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Added Date |
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Wednesday, July 12, 2017 |
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Researchers
| Wang-Ren Qiu | Qiu, Wang-Ren | Researcher | Doctorate | |
| Bi-Qian Sun | Sun, Bi-Qian | Researcher | Doctorate | |
| Xuan Xiao | Xiao, Xuan | Researcher | Doctorate | |
| Zhao-Chun Xu | Xu, Zhao-Chun | Researcher | Doctorate | |
| Kuo-Chen Chou | Chou, Kuo-Chen | Researcher | Doctorate | |
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