Document Details

Document Type : Article In Journal 
Document Title :
Inflammatory mediators in osteoarthritis: A critical review of the state-of-the-art, current prospects, and future challenges
Inflammatory mediators in osteoarthritis: A critical review of the state-of-the-art, current prospects, and future challenges
 
Document Language : English 
Abstract : Osteoarthritis (OA) has traditionally been defined as a prototypical non-inflammatory arthropathy, but today there is compelling evidence to suggest that it has an inflammatory component. Many recent studies have shown the presence of synovitis in a large number of patientswith OA and demonstrated a direct association between joint inflammation and the progression of OA. Pro-inflammatory cytokines, reactive oxygen species (ROS), nitric oxide, matrix degrading enzymes and biomechanical stress are major factors responsible for the progression of OA in synovial joints. The aim of this review is to discuss the significance of a wide range of implicated inflammatory mediators and their contribution to the progression of OA. We also discuss some of the currently available guidelines, practices, and prospects. In addition, this review argues for new innovation in methodologies and instrumentation for the non-invasive detection of inflammation in OA by modern imaging techniques. We propose that identifying early inflammatory events and targeting these alterations will help to ameliorate the major symptoms such as inflammation and pain in OA patients. 
ISSN : 8756-3282 
Journal Name : Bone 
Volume : 85 
Issue Number : 1 
Publishing Year : 1437 AH
2016 AD 
Article Type : Article 
Added Date : Tuesday, July 11, 2017 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Maryam RahmatiRahmati, Maryam ResearcherDoctorate 
Ali MobasheriMobasheri, Ali ResearcherDoctorate 
Masoud MozafariMozafari, Masoud ResearcherDoctorate 

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