Document Details

Document Type : Article In Journal 
Document Title :
Relative biological effectiveness of energetic heavy ions for intestinal tumorigenesis shows male preponderance and radiation type and energy dependence in APC 1638N/+ mice
Relative biological effectiveness of energetic heavy ions for intestinal tumorigenesis shows male preponderance and radiation type and energy dependence in APC 1638N/+ mice
 
Document Language : English 
Abstract : Purpose: There are uncertainties associated with the prediction of colorectal cancer (CRC) risk from highly energetic heavy ion (HZE) radiation. We undertook a comprehensive assessment of intestinal and colonic tumorigenesis induced after exposure to high linear energy transfer (high- LET) HZE radiation spanning a range of dose and LET in a CRC mouse model and compared the results to low-LET g radiation. Methods and Materials: Male and female APC1638N/+ mice (n=20 mice per group) were wholebody exposed to sham-radiation, γ-rays, 12C, 28Si, or 56Fe radiation. For the >1 Gy HZE dose, we used γ-ray equitoxic doses calculated using relative biological effectiveness (RBE) determined previously. Mice were sacrificed 150 days after irradiation, and intestinal and colon tumor frequency was scored. Results: The highest number of tumors was observed after 28Si followed by 56Fe and 12C radiation, and tumorigenesis showed a male preponderance especially after 28Si. Analysis showed greater tumorigenesis per unit of radiation (per cGy) at lower doses suggesting either radiation-induced elimination of target cells or tumorigenesis reaching a saturation point at higher doses. Calculation of RBE for intestinal and colon tumorigenesis showed the highest value with 28Si and lower doses showed greater RBE relative to higher doses. Conclusions: We have demonstrated that the RBE of heavy ion radiation-induced intestinal and colon tumorigenesis is related to ion energy, LET, and gender, and peak RBE is observed at an LET of 69 keV/μm. Our study has implications for understanding risk to astronauts undertaking long duration space missions 
ISSN : 0360-3016 
Journal Name : International Journal of Radiation Oncology Biology Physics 
Volume : 95 
Issue Number : 1 
Publishing Year : 1437 AH
2016 AD 
Article Type : Article 
Added Date : Monday, July 10, 2017 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
S SumanSuman, S ResearcherDoctorate 
S KumarKumar, S ResearcherDoctorate 
BH MoonMoon, BH ResearcherDoctorate 
H ThakorThakor, H ResearcherDoctorate 
Z FanFan, Z ResearcherDoctorate 
JW ShayShay, JW ResearcherDoctorate 
AJ Jr FornaceFornace, AJ Jr ResearcherDoctorate 
K DattaDatta, K ResearcherDoctorate 

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