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Document Type |
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Article In Journal |
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Document Title |
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Osteoarthritis year in review 2015: soluble biomarkers and the BIPED criteria Osteoarthritis year in review 2015: soluble biomarkers and the BIPED criteria |
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Document Language |
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English |
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Abstract |
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Objective: To review and summarize biomarker data published from April 2014 to May 2015 to provide
insight to the ongoing work in the field of osteoarthritis (OA). Furthermore, to summarize the BIPED
criteria and set it in context of the medical needs of 2015.
Methods: PubMed was used as searching machine: Time period 2014/04/01e2015/05/01, MeSH term
[Biomarker] AND [Osteoarthritis], Language; English, Full text available. Reviewswere excluded. Only papers
describing protein based biomarkers measured in human body fluids from OA patients were included.
Results: Biomarkers of joint tissue turnover, cytokines, chemokines and peptide arrays were measured in
different cohorts and studies. Amongst those were previously tested biomarkers such as osteocalcin,
Carboxy-terminal cross-linked fragment of type II collagen (CTX-II) and cartilage oligomeric matrix
protein (COMP). A majority of the biomarker were classified as I, B or B biomarkers according to the
BIPED criteria.
Work is continuing on testing biomarkers in OA. There is still a huge, unmet medical need to identify,
test, validate and qualify novel and well-known biomarkers. A pre-requisite for this is better characterization
and classification of biomarkers to their needs, which may not be reached before higher understanding
of OA phenotypes has been gained. In addition, we provide some references to some recent
guidelines from Food and Drug Administration (FDA) and European Medicines Agency (EMA) on qualification
and usage of biomarkers for drug development and personalized medicine, which may provide
value to the field. |
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ISSN |
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1063-4584 |
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Journal Name |
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Osteoarthritis and cartilage |
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Volume |
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24 |
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Issue Number |
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1 |
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Publishing Year |
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1437 AH
2016 AD |
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Article Type |
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Article |
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Added Date |
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Monday, July 10, 2017 |
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Researchers
| AC Bay-Jensen | Bay-Jensen, AC | Investigator | Doctorate | |
| D. Reker | Reker, D. | Researcher | Doctorate | |
| C.F. Kjelgaard-Petersen | Kjelgaard-Petersen, C.F. | Researcher | Doctorate | |
| C.S. Thudium | Thudium, C.S. | Researcher | Doctorate | |
| M.A. Karsdal | Karsdal, M.A. | Researcher | Doctorate | |
| A. Mobasheri | Mobasheri, A. | Researcher | Doctorate | |
| C. Ladel | Ladel, C. | Researcher | Doctorate | |
| Y. Henrotin | Henrotin, Y. | Researcher | Doctorate | |
|