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Document Type |
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Article In Journal |
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Document Title |
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Mesenchymal stem cells: Identification, phenotypic characterization, biological properties and potential for regenerative medicine through biomaterial micro-engineering of their niche Mesenchymal stem cells: Identification, phenotypic characterization, biological properties and potential for regenerative medicine through biomaterial micro-engineering of their niche |
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Document Language |
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English |
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Abstract |
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Mesenchymal stem cells (MSCs) are multipotent stem cells. Although they were originally identified in
bone marrow and described as ‘marrow stromal cells’, they have since been identified in many other
anatomical locations in the body. MSCs can be isolated from bone marrow, adipose tissue, umbilical cord
and other tissues but the richest tissue source of MSCs is fat. Since they are adherent to plastic, they may
be expanded in vitro. MSCs have a distinct morphology and express a specific set of CD (cluster of
differentiation) molecules. The phenotypic pattern for the identification of MSCs cells requires expression
of CD73, CD90, and CD105 and lack of CD34, CD45, and HLA-DR antigens. Under appropriate
micro-environmental conditions MSCs can proliferate and give rise to other cell types. Therefore, they
are ideally suited for the treatment of systemic inflammatory and autoimmune conditions. They have
also been implicated as key players in regenerating injured tissue following injury and trauma. MSC populations
isolated from adipose tissue may also contain regulatory T (Treg) cells, which have the capacity
for modulating the immune system. The immunoregulatory and regenerative properties of MSCs
make them ideal for use as therapeutic agents in vivo. In this paper we review the literature on the identification,
phenotypic characterization and biological properties of MSCs and discuss their potential for
applications in cell therapy and regenerative medicine. We also discuss strategies for biomaterial
micro-engineering of the stem cell niche. |
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ISSN |
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1046-2023 |
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Journal Name |
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Methods |
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Volume |
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99 |
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Issue Number |
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1 |
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Publishing Year |
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1437 AH
2016 AD |
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Article Type |
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Article |
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Added Date |
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Monday, July 10, 2017 |
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Researchers
| Julianna Kobolak | Kobolak, Julianna | Researcher | Doctorate | |
| Andras Dinnyes | Dinnyes, Andras | Researcher | Doctorate | |
| Adnan Memic | Memic, Adnan | Researcher | Doctorate | |
| Ali Khademhosseini | Khademhosseini, Ali | Researcher | Doctorate | |
| Ali Mobasheri | Mobasheri, Ali | Researcher | Doctorate | |
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