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Document Type |
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Article In Journal |
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Document Title |
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Garlic extract attenuates immobilization stress-induced alterations in plasma antioxidant/oxidant parameters and hepatic function in rats Garlic extract attenuates immobilization stress-induced alterations in plasma antioxidant/oxidant parameters and hepatic function in rats |
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Document Language |
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English |
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Abstract |
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Objective: To investigate the oxidative stress induced by 6 h of immobilization stress in Albino
Wistar rats. Further, the pre- and post-treatment of aqueous garlic extract was studied to evaluate its preventive
and curative efficacy on stress-induced altered oxidative parameters in rats. Methods: Albino Wistar rats
were exposed to 6 h of immobilization stress, and received garlic extract (100 mg/kg body weight) treatment
pre- or post-stress exposure. The oxidative status of plasma after various treatments were evaluated by
determining the levels of reduced glutathione, glucose, uric acid, thiobarbituric acid reactive substances,
aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and the activities
of superoxide dismutase, catalase and glutathione-S-transferase by standardized procedures. Results:
Immobilization of rats generated oxidative stress in rat plasma, by decreasing the activities of antioxidant enzymes,
glutathione levels and glucose, while increasing the lipid peroxidation, serum glutamic oxaloacetic transaminase,
serum glutamic pyruvic transaminase, ALP and uric acid compared to the non-stressed controls (P<0.01). The
garlic extract administration both pre- and post-stress exposure signifi cantly prevented the rise in the diagnostic
liver enzymes and reverted the decrease of antioxidant enzymatic activities compared to the stressed group (P<0.05
or P <0.01). Post-stress treatment of extract was found more effective than pre-stress treatment in reverting
the values back to normal (P<0.01). Conclusion: Garlic extract seems promising as a nutritional supplement for
scavenging free radicals generated in the plasma and to prevent resulting oxidative stress. |
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ISSN |
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1672-0415 |
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Journal Name |
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Chinese Journal of Integrative Medicine |
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Volume |
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1 |
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Issue Number |
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1 |
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Publishing Year |
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1438 AH
2017 AD |
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Article Type |
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Article |
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Added Date |
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Tuesday, May 16, 2017 |
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Researchers
| Syed Kashif Zaidi | Zaidi, Syed Kashif | Investigator | Doctorate | |
| Shakeel Ahmed Ansari | Ansari, Shakeel Ahmed | Researcher | Doctorate | |
| Shams Tabrez | Tabrez, Shams | Researcher | Doctorate | |
| Md Nasrul Hoda | Hoda, Md Nasrul | Researcher | Doctorate | |
| Ghulam Md Ashraf | Ashraf, Ghulam Md | Researcher | Doctorate | |
| Mohd Shahnawaz Khan | Khan, Mohd Shahnawaz | Researcher | Doctorate | |
| Sultan Alnohair | Alnohair, Sultan | Researcher | Doctorate | |
| Naheed Banu | Banu, Naheed | Researcher | Doctorate | |
| Mohammed Hussain Al-Qahtani | Al-Qahtani, Mohammed Hussain | Researcher | | |
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