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Document Type |
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Article In Journal |
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Document Title |
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Impact of various progestins with or without transdermal testosterone on gonadotropin levels for non‐invasive hormonal male contraception: a randomized clinical trial Impact of various progestins with or without transdermal testosterone on gonadotropin levels for non‐invasive hormonal male contraception: a randomized clinical trial |
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Document Language |
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English |
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Abstract |
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Although several progestins have been tested for hormonal male contraception, the effects of dosage and nature of various progestins
on gonadotropin suppression combined with and without additional testosterone has not been performed in a comparative
trial. The aim of this study was to evaluate the differential impact of four oral or transdermal progestins on the suppression of gonadotropins
in healthy men: oral: cyproterone acetate (CPA), levonorgestrel (LNG), norethisterone acetate (NETA), and transdermal:
Nestorone (NES), all in combination with transdermal testosterone (T). Randomized clinical trial testing was performed with four
progestins at two doses each. After a 2-week progestin-only treatment, transdermal T was added for further 4 weeks and was followed
by a 3-week recovery period. Progestin-dose per day: CPA 10 mg/20 mg, NES 2 mg/3 mg/dose e.g. 200/300 lg/day absorbed,
NETA 5 mg/10 mg, LNG 120 lg/240 lg. From an andrology outpatient clinic, 56 healthy men aged 18–50 years, with body mass
index ≤33 kg 9 m
2 were included in the study. Serum concentrations of luteinizing hormone (LH) and follicle-stimulating hormone
(FSH) were studied. Secondary outcome measure included were serum testosterone concentrations, sperm concentrations, and
safety parameters. Intergroup comparisons demonstrated that CPA and LNG had the strongest effect on LH/FSH suppression. Nevertheless,
every substance showed significant inhibitory effects on gonadotropin secretion, especially in combination with transdermal
T. A decrease in hematocrit and insulin sensitivity as well as cholesterol subfractions and triglycerides was uniformly seen for every
group. The combination of oral or transdermal progestins with a transdermal testosterone preparation is able to suppress gonadotropins.
Further dose titration studies with sperm suppression as an end-point should be conducted to determine the lowest effective
dose for hormonal male contraception. |
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ISSN |
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2047-2927 |
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Journal Name |
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Andrology |
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Volume |
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5 |
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Issue Number |
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3 |
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Publishing Year |
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1438 AH
2017 AD |
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Article Type |
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Article |
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Added Date |
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Tuesday, May 16, 2017 |
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Researchers
| M Zitzmann | Zitzmann, M | Investigator | Doctorate | |
| J Rohayem | Rohayem, J | Researcher | Doctorate | |
| J Raidt | Raidt, J | Researcher | Doctorate | |
| S Kliesch | Kliesch, S | Researcher | Doctorate | |
| N Kumar | Kumar, N | Researcher | Doctorate | |
| R Sitruk-Ware | Sitruk-Ware, R | Researcher | Doctorate | |
| E Nieschlag | Nieschlag, E | Researcher | Doctorate | |
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