Document Details

Document Type : Article In Journal 
Document Title :
Low expression of leptin and its association with breast cancer: A transcriptomic study
Low expression of leptin and its association with breast cancer: A transcriptomic study
 
Document Language : English 
Abstract : The incidence of breast cancer is alarmingly increasing worldwide and also among Saudi women. Obesity is linked with an increased cancer risk and studies have also revealed that leptin may be involved in breast tumorigenesis particularly among obese women. Numerous transcriptomic studies have been carried out worldwide; however, molecular studies among breast cancer patients of diverse ethnic groups from the Arabian Peninsula are scarce. In the present study, whole transcriptome analysis of 45 surgically resected breast tumors from Saudi Arabian female patients was carried out. Expression data were analyzed, and molecular networks and canonical pathways were identified. We identified 1,159 differentially expressed genes using p-value with a false discovery rate <0.05 and a fold-change >2 as a cut-off. Using ingenuity pathway analysis tool, we identified many canonical pathways that were implicated in breast cancer for the first time. Notably, along with other lipid metabolism molecules, leptin (LEP) was one of the most downregulated genes (fold cut-off, -7.03) with significant differences between the breast cancer and the control groups (p<0.0001) and was further confirmed in all the samples using qPCR. Transcriptomic profiling of breast cancer from a Saudi female population revealed downregulation of LEP. Molecular pathway analysis demonstrated the role of LEP and other associated molecules of the lipid metabolism pathway. Involvement of leptin and lipid metabolism in breast cancer was highlighted. The majority of cases presented were of late stage, stressing the need to educate individuals concerning early diagnostic testing and the life-style risk factors for breast cancer such as unhealthy diet and obesity 
ISSN : 1021-335X 
Journal Name : Oncology Reports 
Volume : 36 
Issue Number : 1 
Publishing Year : 1437 AH
2016 AD 
Article Type : Article 
Added Date : Wednesday, October 5, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Mohammed Al-QahtaniAl-Qahtani, Mohammed ResearcherDoctorate 
SAJJAD KARIMKARIM, SAJJAD InvestigatorDoctorate 
HANS-JUERGEN SCHULTENSCHULTEN, HANS-JUERGEN ResearcherDoctorate 
ASHRAF DALLOLDALLOL, ASHRAF ResearcherDoctorate 
ABDELBASET BUHMEIDABUHMEIDA, ABDELBASET ResearcherDoctorate 
MAMDOOH GARIGARI, MAMDOOH ResearcherDoctorate 
ADEEL CHAUDHARYCHAUDHARY, ADEEL ResearcherDoctorate 
ADEL ABUZENADAHABUZENADAH, ADEL. ResearcherDoctorate 
ADNAN MERDADMERDAD, ADNAN ResearcherDoctorate 
FATIMA AL-THUBAITYAL-THUBAITY, FATIMA ResearcherDoctorate 
MANIKANDAN JAYAPALJAYAPAL, MANIKANDAN ResearcherDoctorate 
ZEENAT MIRZAMIRZA, ZEENAT ResearcherDoctorate 

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