Document Details

Document Type : Article In Journal 
Document Title :
Protective Effect of Solanum nigrum Leaves Extract on Immobilization Stress Induced Changes in Rat's Brain
Protective Effect of Solanum nigrum Leaves Extract on Immobilization Stress Induced Changes in Rat's Brain
 
Document Language : English 
Abstract : The prophylactic or curative antioxidant efficacy of crude extract and the active constituent of S. nigrum leaves were evaluated in modulating inherent antioxidant system altered due to immobilization stress in rat brain tissues, in terms of measurement of glutathione (GSH), lipid peroxidation (thiobarbituric acid reactive substances, TBARS), and free radical scavenging enzymes activities. Rats were treated with single dose of crude extract of S. nigrum prior to and after 6 h of immobilization stress exposure. Exposure to immobilization stress resulted in a decrease in the brain levels of glutathione, SOD, GST, and catalase, with an increase in thiobarbituric acid reactive substances (TBARS) levels. Treatment of S. nigrum extract and its active constituents to both pre- and poststressed rats resulted in significant modulation in the above mentioned parameters towards their control values with a relative dominance by the latter. Brain is vulnerable to stress induced prooxidant insult due to high levels of fat content. Thus, as a safe herbal medication the S. nigrum leaves extract or its isolated constituents can be used as nutritional supplement for scavenging free radicals generated in the brain due to physical or psychological stress or any neuronal diseases per se 
ISSN : 1741-427X 
Journal Name : Evid Based Complement Alternat Med 
Volume : 2014 
Issue Number : 912450 
Publishing Year : 1436 AH
2015 AD 
Article Type : Article 
Added Date : Sunday, May 1, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Syed Kashif ZaidiZaidi, Syed KashifInvestigator  
Md. Nasrul HodaHoda, Md. NasrulResearcher  
Shams TabrezTabrez, Shams Researcher  
Shakeel Ahmed AnsariAnsari, Shakeel AhmedResearcher  
Mohammad Alam JafriJafri, Mohammad AlamResearcher  
Mohd Shahnawaz KhanKhan, Mohd ShahnawazResearcher  
Shirin HasanHasan, Shirin Researcher  
Mohammed H. AlqahtaniAlqahtani, Mohammed H.Researcher  
Adel Mohammed AbuzenadahAbuzenadah, Adel MohammedResearcher  
Naheed BanuBanu, Naheed Researcher  

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