Document Details

Document Type : Article In Journal 
Document Title :
Association between SNPs of Metalloproteinases and Prostaglandin F2α Receptor Genes and Latanoprost Response in Open-Angle Glaucoma
Association between SNPs of Metalloproteinases and Prostaglandin F2α Receptor Genes and Latanoprost Response in Open-Angle Glaucoma
 
Document Language : English 
Abstract : PURPOSE: To determine whether single nucleotide polymorphisms (SNPs) of genes coding for matrix metalloproteinases (MMPs) and the prostaglandin F2α receptor gene (PTGFR) are related to a response to latanoprost in a white Spanish population of glaucomatous patients. DESIGN: Case-control study. PARTICIPANTS: One hundred twenty-four patients with open-angle glaucoma. METHODS: Genotyping was performed in 117 patients with primary open-angle glaucoma with a minimum treatment duration of 4 weeks. Candidate genes and individual polymorphisms were selected according to the effect on the mechanism of action of latanoprost. Multi-SNP haplotype analyses for associations also were tested. MAIN OUTCOME MEASURES: Diurnal intraocular pressure reduction and genotyping of the SNPs in the MMPs and PTGFR. RESULTS: The PTGFR SNPs were associated with positive (rs6686438, rs10786455) and negative (rs3753380, rs6672484, rs11578155) responses to latanoprost. Multiple testing found 2 genes, PTGFR and MMP-1, were related to refractoriness to latanoprost. CONCLUSIONS: The SNPs of the PTGFR and MMP-1 genes may determine the latanoprost response in a white European Spanish population. This study identified 5 SNPs related to the latanoprost response; 1 SNP, rs3753380, already has been associated with a poor response to latanoprost in a healthy Japanese population. Latanoprost is a commonly used antiglaucomatous drug, and increased knowledge of its mechanism of action will lead to advances in pharmacogenetics. 
ISSN : 0161-6420 
Journal Name : Ophthalmology 
Volume : 122 
Issue Number : 5 
Publishing Year : 1436 AH
2015 AD 
Article Type : Article 
Added Date : Sunday, May 1, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Fernando UssaUssa, Fernando Investigator ussa@ioba.med.uva.es
Itziar FernandezFernandez, Itziar Researcher  
Maria BrionBrion, Maria Researcher  
Angel CarracedoCarracedo, Angel Researcher  
Francisco BlazquezBlazquez, Francisco Researcher  
Maria T GarciaGarcia, Maria TResearcher  
Ana Sanchez-JaraSanchez-Jara, Ana Researcher  
Lourdes De Juan-MarcosDe Juan-Marcos, Lourdes Researcher  
Soledad Jimenez-CarmonaJimenez-Carmona, Soledad Researcher  
Jose R JuberiasJuberias, Jose RResearcher  
J M Martinez-de-la-CasaMartinez-de-la-Casa, J MResearcher  
J C PastorPastor, J CResearcher  

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