Document Details

Document Type : Article In Journal 
Document Title :
Exploration of SNP variants affecting hair colour prediction in Europeans
Exploration of SNP variants affecting hair colour prediction in Europeans
 
Document Language : English 
Abstract : DNA profiling is a key tool for forensic analysis; however, current methods identify a suspect either by direct comparison or from DNA database searches. In cases with unidentified suspects, prediction of visible physical traits e.g. pigmentation or hair distribution of the DNA donors can provide important probative information. This study aimed to explore single nucleotide polymorphism (SNP) variants for their effect on hair colour prediction. A discovery panel of 63 SNPs consisting of already established hair colour markers from the HIrisPlex hair colour phenotyping assay as well as additional markers for which associations to human pigmentation traits were previously identified was used to develop multiplex assays based on SNaPshot single-base extension technology. A genotyping study was performed on a range of European populations (n = 605). Hair colour phenotyping was accomplished by matching donor's hair to a graded colour category system of reference shades and photography. Since multiple SNPs in combination contribute in varying degrees to hair colour predictability in Europeans, we aimed to compile a compact marker set that could provide a reliable hair colour inference from the fewest SNPs. The predictive approach developed uses a naïve Bayes classifier to provide hair colour assignment probabilities for the SNP profiles of the key SNPs and was embedded into the Snipper online SNP classifier ( http://mathgene.usc.es/snipper/ ). Results indicate that red, blond, brown and black hair colours are predictable with informative probabilities in a high proportion of cases. Our study resulted in the identification of 12 most strongly associated SNPs to hair pigmentation variation in six genes. 
ISSN : 1437-1596 
Journal Name : Int J Legal Med 
Volume : 129 
Issue Number : 5 
Publishing Year : 1436 AH
2015 AD 
Article Type : Article 
Added Date : Thursday, April 28, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Jens SöchtigSöchtig, Jens Investigator  
Chris PhillipsPhillips, Chris Researcher  
Olalla MaroñasMaroñas, Olalla Researcher  
Antonio Gómez-TatoGómez-Tato, Antonio Researcher  
Raquel CruzCruz, Raquel Researcher  
Jose Alvarez-DiosAlvarez-Dios, Jose Researcher  
María-Ángeles Casares de CalCal, María-Ángeles Casares deResearcher  
Yarimar RuizRuiz, Yarimar Researcher  
Kristian ReichReich, Kristian Researcher  
Manuel FondevilaFondevila, Manuel Researcher  
Ángel CarracedoCarracedo, Ángel Researcher  
María V. Lareu`Lareu, María V.Researcher  

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